Comparing plasma proteins and metabolites in coronary artery disease patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate and compare the plasma proteomic and metabolomic profiles of three groups of patients: those without atherosclerotic lesions, those with non-obstructive lesions (less than 50%), and those with obstructive lesions (50% or more). By utilizing coronary computed tomography angiography (CCTA) and invasive coronary angiography (ICA), the study seeks to identify potential prognostic biomarkers associated with coronary artery disease (CAD) and their relationship with clinical events. The research focuses on discovering novel biological indicators that could lead to personalized therapies for patients, particularly those with non-obstructive lesions who are at risk for coronary events.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Group I: Patients without manifest atherosclerotic disease (no history of angina, previous myocardial infarction, prior revascularization, cerebrovascular disease, or peripheral vascular disease).
2. Group II: Patients with non-obstructive coronary lesions (\< 50%) detected on coronary computed tomography angiography (CCTA) or invasive coronary angiography (ICA).
3. Group III: Patients with obstructive coronary lesions (≥ 50%) detected on CCTA or ICA.

Exclusion Criteria:

1. Patients who refuse to sign the informed consent form (ICF);
2. Individuals with non-atherosclerotic heart disease (such as valvular diseases, cardiomyopathies, or congenital heart diseases);
3. Severe nephropathy (creatinine clearance \< 30 mL/min/1.73 m² body surface area);
4. Malignant neoplasms or other chronic diseases with poor prognosis;
5. Patients with acute coronary syndromes within the last 90 days;
6. Active smoking.

Where it's running

• Instituto do Coração InCor, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo
  São Paulo, São Paulo, Brazil Recruiting

Study contacts

• Principal investigator: Protasio da Luz PhD — Instituto do Coração InCor, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo
• Study coordinator: Vinícius Quintão MD
• Email: vinicius.quintao@hc.fm.usp.br
• Phone: 55 11 2661-5795

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.