Combining CT Angiography and Perfusion for Heart Disease Assessment
Combined Coronary CT Angiography and CT Perfusion in Coronary Artery Disease: Integrating Plaque Morphology, Hemodynamics, and Perfusion for Precision Management
This study is testing if using a combination of advanced heart imaging techniques can help doctors better understand and treat people with coronary artery disease.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 2000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Shanghai Zhongshan Hospital Academic / other |
| Locations | 1 site (Shanghai, Shanghai Municipality) |
| Trial ID | NCT06949150 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of combining coronary computed tomography angiography (CTA) and CT myocardial perfusion (CTP) to improve the assessment of coronary artery disease (CAD). It aims to address the limitations of CTA in determining the functional significance of coronary lesions by integrating hemodynamic parameters and myocardial blood flow measurements. The study will analyze long-term outcomes and the prognostic implications of combined findings, focusing on plaque characteristics and perfusion deficits. By enhancing diagnostic accuracy, this approach seeks to improve risk stratification for patients with CAD.
Who should consider this trial
Good fit: Ideal candidates include patients with indications for CT perfusion who can provide informed consent.
Not a fit: Patients with severe heart dysfunction, recent heart attacks, or those requiring immediate surgical intervention may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more accurate diagnoses and better management strategies for patients with coronary artery disease.
How similar studies have performed: Previous studies have shown promising results with similar approaches, but the integration of CTA and CTP for comprehensive assessment remains an area needing further validation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Patients with an indication for CTP. Qualified patients who have signed a written informed consent form. Exclusion Criteria: * Left ventricular ejection fraction \< 35%； * Acute ST-elevation myocardial infarction within 3 months or previous coronary artery bypass graft surgery； * Planned coronary artery bypass graft surgery after diagnostic angiography； * Poor quality of CTA/CTP or other reasons by core lab that are unsuitable for plaque, physiological or fat analysis； * Contraindications for CT perfusion or coronary angiography； * Coexisting conditions such as pregnancy, cancer, severe valvular heart disease, or liver/kidney dysfunction； * Other diseases with a life expectancy of less than one year； * Inability to sign informed consent or, in the researcher's judgment, poor compliance, making it unlikely the patient can complete the study as required.
Where this trial is running
Shanghai, Shanghai Municipality
- Zhongshan Hospital Fudan University — Shanghai, Shanghai Municipality, China (Recruiting)
Study contacts
- Study coordinator: Wei Gao, PHD
- Email: gao.wei1@zs-hospital.sh.cn
- Phone: +8613661959824
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.