Combining CT Angiography and Perfusion for Heart Disease Assessment
Official title: Combined Coronary CT Angiography and CT Perfusion in Coronary Artery Disease: Integrating Plaque Morphology, Hemodynamics, and Perfusion for Precision Management
Run by Shanghai Zhongshan Hospital · NCT06949150 · Data updated 2026-11-12
This study is testing if using a combination of advanced heart imaging techniques can help doctors better understand and treat people with coronary artery disease.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 2000 (estimated) |
| Sponsor | Shanghai Zhongshan Hospital Academic / other |
| Locations | 1 site (Shanghai, Shanghai Municipality) |
| Status | Recruiting |
| Started | January 1, 2025 |
| Main results expected | December 31, 2029 |
| Study ends | December 31, 2034 |
| Registry record updated | April 29, 2025 |
| Trial ID | NCT06949150 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include patients with indications for CT perfusion who can provide informed consent.
✕Probably not a fit
Patients with severe heart dysfunction, recent heart attacks, or those requiring immediate surgical intervention may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness of combining coronary computed tomography angiography (CTA) and CT myocardial perfusion (CTP) to improve the assessment of coronary artery disease (CAD). It aims to address the limitations of CTA in determining the functional significance of coronary lesions by integrating hemodynamic parameters and myocardial blood flow measurements. The study will analyze long-term outcomes and the prognostic implications of combined findings, focusing on plaque characteristics and perfusion deficits. By enhancing diagnostic accuracy, this approach seeks to improve risk stratification for patients with CAD.
Why it matters
Potential benefit: If successful, this study could lead to more accurate diagnoses and better management strategies for patients with coronary artery disease.
How similar studies have gone: Previous studies have shown promising results with similar approaches, but the integration of CTA and CTP for comprehensive assessment remains an area needing further validation.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Patients with an indication for CTP. Qualified patients who have signed a written informed consent form. Exclusion Criteria: * Left ventricular ejection fraction \< 35%； * Acute ST-elevation myocardial infarction within 3 months or previous coronary artery bypass graft surgery； * Planned coronary artery bypass graft surgery after diagnostic angiography； * Poor quality of CTA/CTP or other reasons by core lab that are unsuitable for plaque, physiological or fat analysis； * Contraindications for CT perfusion or coronary angiography； * Coexisting conditions such as pregnancy, cancer, severe valvular heart disease, or liver/kidney dysfunction； * Other diseases with a life expectancy of less than one year； * Inability to sign informed consent or, in the researcher's judgment, poor compliance, making it unlikely the patient can complete the study as required.
Where it's running
-
Zhongshan Hospital Fudan University
Shanghai, Shanghai Municipality, China Recruiting
Study contacts
- Study coordinator: Wei Gao, PHD
- Email: gao.wei1@zs-hospital.sh.cn
- Phone: +8613661959824
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.