Evaluating heart function and blood flow in patients with coronary artery disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess mechanical dyssynchrony of the left ventricle using SPECT imaging in patients with coronary microvascular dysfunction and chronic coronary heart disease. Participants will undergo a two-day protocol involving blood sampling and dynamic SPECT imaging, including a resting phase followed by stress testing with dobutamine. The study will categorize patients based on their myocardial blood flow reserve, providing insights into the relationship between mechanical dyssynchrony and coronary microvascular function.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Ischemia with no obstructive coronary arteries (INOCA)
* Obstructive coronary artery disease (CAD)
* Patients without evidence of coronary heart disease

Exclusion Criteria:

* Left ventricular ejection fraction \<55% according to echocardiography;
* History of myocardial infarction/revascularization;
* hypertension: systolic blood pressure \>180 mm Hg. Art., diastolic BP\>110 mm Hg. Art.;
* systolic arterial hypotension \<80 mm Hg. Art.;
* atrial fibrillation;
* AV blockade of the III degree; sick sinus syndrome;
* massive pulmonary embolism (PE) with a high degree of pulmonary hypertension;
* the presence of significant valvular pathology (mitral insufficiency ≥ 3 degrees, aortic insufficiency ≥ 3 degrees, tricuspid regurgitation ≥ 3 degrees).
* severe course of bronchial asthma, chronic obstructive pulmonary disease;
* decompensated type 2 diabetes,
* severe liver or kidney failure (glomerular filtration rate \<50 ml/min/1.73 m3 (CKD-EPI),
* morbid obesity (body mass index \>45);
* history of myocarditis
* indications of poor drug tolerance;
* oncological diseases;
* chronic alcoholism, mental disorders;
* other severe comorbidity,
* refusal to participate in the study.

Where it's running

• Tomsk NRMC Cardiology Research Institute
  Tomsk, Russia Recruiting

Study contacts

• Principal investigator: Vladimir V Shipulin, MD, PhD — Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
• Study coordinator: Vladimir V Shipulin, MD, PhD
• Email: shipartphoto@gmail.com
• Phone: +79521575263

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.