AI detection of hidden coronary occlusions and timing of treatment for heart attacks
Official title: Artificial Intelligence Based Timing, Infarct Size and Outcomes in Acute Coronary Occlusion Myocardial Infarction Without ST Elevation
Run by Azienda Ospedaliera di Bolzano · NCT06910436 · Data updated 2026-11-12
This project tests whether an AI reading of 12‑lead ECGs can find hidden coronary occlusions in adults with suspected non‑ST‑elevation ACS and whether the time to PCI after that detection relates to troponin peak levels.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 1500 (estimated) |
| Sponsor | Azienda Ospedaliera di Bolzano Academic / other |
| Locations | 1 site (Bolzano, BZ) |
| Status | Recruiting |
| Started | April 1, 2024 |
| Main results expected | July 31, 2026 |
| Study ends | July 31, 2026 |
| Registry record updated | May 26, 2026 |
| Trial ID | NCT06910436 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults over 18 with a working diagnosis of non‑ST‑elevation ACS who have good‑quality digital 12‑lead ECGs and are scheduled for invasive coronary angiography are the intended participants.
✕Probably not a fit
Patients with ST‑elevation MI, poor or corrupted ECG digitalization, major sustained ventricular arrhythmias, or those under 18 are unlikely to benefit from this AI evaluation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective observational study that applies an artificial intelligence ECG model to adults presenting with suspected non‑ST‑elevation acute coronary syndrome who undergo routine invasive coronary angiography. The AI model will be used to identify occlusion myocardial infarction (OMI) from digitized 12‑lead ECGs while usual clinical care pathways are maintained. For patients the study identifies as having OMI, investigators will record the elapsed time from diagnosis to PCI and compare peak troponin values across different timing intervals. Coronary angiogram findings and routine clinical data will be collected to link AI ECG findings with angiographic occlusion and biochemical evidence of infarction.
Why it matters
Potential benefit: If successful, the approach could help clinicians find occult coronary occlusions earlier so that timely PCI reduces infarct size and potential complications.
How similar studies have gone: Previous research has shown promising results for AI algorithms in detecting occult coronary occlusion patterns on ECGs, but few prospective observational studies have directly linked AI detection to timing of reperfusion and infarct size.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \> 18 yrs * Working diagnosis of Non- ST Elevation Acute Coronary Syndrome after the assessment by specialist Exclusion Criteria: * ST-Elevation Myocardial infarction * Age \< 18 yrs * Major sustained ventricular arrhythmias * Corrupted ECG images * Poor digitalisation quality of the ECG
Where it's running
-
Azienda Sanitaria di Bolzano
Bolzano, Bz, Italy Recruiting
Study contacts
- Study coordinator: Matthias Unterhuber, MD, Associate Prof.
- Email: matthias.unterhuber@gmail.com
- Phone: +39 471 43 9950
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Red grape juice and metabolism in men with coronary disease
Researchers will test whether daily red grape juice changes the blood metabolite profile in men with chronic coronary artery disease.
-
Rapid guideline-based therapy after a heart attack
This project tests whether starting guideline-driven secondary prevention soon after a heart attack helps people who had PCI reach better risk-factor control and fewer heart events.
-
Edoxaban vs. Apixaban in AF with CAD: Net Benefit
This trial tests whether edoxaban-based therapy provides a similar or better overall benefit than apixaban-based therapy for stroke prevention and major bleeding in adults with atrial fibrillation and coronary artery disease.
-
Revascularization of Calcified Coronary Arteries
This study tests whether measuring blood flow and pressure before and after ballooning or stenting of calcified coronary arteries can help predict how well the procedure will work for adults with heart disease.
-
OPN Balloon Use for Recanalization of Calcified Coronary Lesions
This registry tests how the SIS-OPN balloon is used in real-world patients with calcified coronary disease who have undergone PCI in North America.
-
Pulse IVL to open calcified coronary vessels in CAD
A small, early feasibility study tests the Pulse Intravascular Lithotripsy system in adults with coronary artery disease to see if it can safely open calcified arteries and improve vessel compliance.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.