Comparing two techniques for treating complex coronary bifurcation lesions
Official title: Comparison of Cardiovascular Outcomes of Double Kissing-crush vs Controlled Balloon-crush Techniques For Complex Coronary Bifurcation Lesions
Run by Istanbul Mehmet Akif Ersoy Educational and Training Hospital · NCT06931574 · Data updated 2026-11-12
This study is testing two different ways to treat complex heart artery blockages to see which one helps patients feel better and have fewer heart problems after the procedure.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | Istanbul Mehmet Akif Ersoy Educational and Training Hospital Government |
| Locations | 2 sites (Istanbul and 1 other locations) |
| Status | Recruiting |
| Started | April 1, 2025 |
| Main results expected | November 1, 2026 |
| Study ends | December 30, 2026 |
| Registry record updated | April 17, 2025 |
| Trial ID | NCT06931574 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults over 18 with complex coronary bifurcation lesions suitable for PCI using either the double kissing-crush or controlled balloon-crush techniques.
✕Probably not a fit
Patients with non-complex bifurcation anatomy or those with severe conditions such as ST-elevation myocardial infarction or end-stage organ disease may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness of two techniques, double kissing-crush and controlled balloon-crush, for treating complex coronary bifurcation lesions in patients undergoing percutaneous coronary intervention (PCI). The double kissing-crush technique aims to improve outcomes by reducing major adverse cardiovascular events compared to traditional methods. The controlled balloon-crush technique is a newer approach that allows for easier rewiring of the side branch, potentially enhancing procedural success. The study will observe patients aged over 18 with specific coronary lesion types to determine which technique yields better results.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment outcomes for patients with complex coronary bifurcation lesions.
How similar studies have gone: Previous studies have shown promising results with the double kissing-crush technique, indicating potential success for this comparative approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged \>18 * PCI with either DK-crush or Controlled balloon-crush * Complex coronary bifurcation lesion (Medina 0.1.1, Medina 1.1.1) Exclusion Criteria: * Non-complex bifurcation anatomy * Bail-out 2-stent (reverse modified mini-crush) * ST-elevation myocardial infarction * Cardiogenic shock status * In-stent restenosis * A previous of coronary artery bypass grafting * Implantation of bare-metal stent * End-stage hepatic or renal disease * \<1-year life expectancy
Where it's running
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Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital
Istanbul, Turkey (Türkiye) Recruiting -
Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital
Istanbul, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Fatih Uzun, Professor
- Email: fatihuzun28@gmail.com
- Phone: 902126922000
Similar studies
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This study tests whether using a thinner-strut bioresorbable scaffold with OCT/IVUS imaging guidance improves outcomes in adults with stable CAD undergoing PCI.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.