Condition

Bone Metastases clinical trials and research

• 21Clinical trials
• 4NIH research projects
• 11Countries

Newest Bone Metastases clinical trials

All recruiting trials (21)

• Prophylactic Radiotherapy to Prevent Bone Complications in Metastatic Cancers

  This study tests whether giving early radiotherapy to high-risk bone metastases, in addition to standard care, can reduce bone-related problems in adults with metastatic solid cancers.

  Recruiting Phase 2 Institute of Oncology Ljubljana · Ljubljana · NCT07540650

• Focused high-dose SBRT for spinal tumors

  This program will try focused high-dose SBRT for adults with spinal metastases to track side effects and local tumor control during routine care.

  Recruiting at 2 sites Institute of Oncology Ljubljana · Ljubljana and 1 other locations · NCT07429422

• Registry for people with symptomatic bone metastases

  This registry collects health information from adults with symptomatic bone metastases who need treatment for painful or unstable bone lesions to learn more about outcomes and care.

  Recruiting at 7 sites Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT07391410

• One-visit, simulation-free single-dose radiation for painful bone metastases

  This trial tests whether adults with one or two painful bone metastases can get pain-relieving radiation in a single visit using a simulation-free planning approach.

  Recruiting University of Utah · Salt Lake City, Utah · NCT07202273

• Dual Energy CT to Delineate Tumors and Organs at Risk in Radiotherapy

  This study tests whether dual-energy CT can delineate tumors and nearby critical tissues as well as MRI for patients needing radiotherapy.

  Recruiting at 2 sites Aalborg University Hospital · Aalborg and 2 other locations · NCT07185958

• Early radiotherapy versus observation for high‑risk painless or minimally painful bone metastases

  This will test whether giving preventive radiotherapy to people with high‑risk but painless or minimally painful bone metastases can reduce future bone complications, hospital stays, and symptoms compared with observation and usual treatment.

  Recruiting at 6 sites Cancer Research Antwerp · Wilrijk, Antwerp and 7 other locations · NCT07146074

• Analysis of surgical treatments for bone metastases in the proximal femur

  This study looks at how well different surgical treatments for bone metastases in the upper thigh bone work for patients who have had fractures.

  Recruiting Istituto Ortopedico Rizzoli · Bologna, Emilia-Romagna · NCT06918860

• Combination of Tislelizumab and Nab-Paclitaxel for Advanced Triple-Negative Breast Cancer with Bone Metastasis

  This study is testing if a new combination of Tislelizumab and Nab-Paclitaxel can effectively treat patients with advanced triple-negative breast cancer that has spread to their bones.

  Recruiting Phase 2 Zhejiang Cancer Hospital · Hangzhou, Zhejiang · NCT06538896

• Evaluating fracture risk in patients with bone metastases from cancer

  This study looks at medical records of cancer patients with bone metastases to see if it can find ways to predict their risk of fractures.

  Recruiting Istituto Ortopedico Rizzoli · Bologna, Emilia-Romagna · NCT06524843

• Curative cryoablation for up to three bone metastases

  This prospective registry will try cryoablation with curative intent to treat up to three bone metastases in adults with oligometastatic or oligo-progressive solid tumors and record effects on pain, quality of life, safety, and tumor control.

  Recruiting at 5 sites Cardiovascular and Interventional Radiological Society of Europe · Bordeaux and 4 other locations · NCT06480955

• Evaluating Incadronate for Breast Cancer with Bone Metastases

  This study is testing if incadronate can help people with breast cancer that has spread to their bones feel better and stay safe while using the treatment.

  Recruiting Fudan University · Shanghai, Shanghai Municipality · NCT06392217

• Database for patients with bone metastases

  This study is collecting information from adults with bone metastases to help improve understanding and treatment of the condition.

  Recruiting at 29 sites Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS · Imola, Bologna and 29 other locations · NCT06367491

• Radiotherapy for limb neoplasms

  This study looks at how well radiotherapy works for people with tumors in their arms or legs to find the best treatment options.

  Recruiting European Institute of Oncology · Milan · NCT06335251

• Using arterial embolization to treat bone metastases

  This study is testing whether a minimally invasive treatment called arterial embolization can help reduce pain and improve outcomes for patients with bone metastases.

  Recruiting Istituto Ortopedico Rizzoli · Bologna, Emilia-Romagna · NCT06189079

• Comparing two types of radiation therapy for painful bone metastases

  This study is testing whether a new type of radiation therapy can help people with painful bone metastases feel better compared to the standard treatment.

  Recruiting Phase 3 M.D. Anderson Cancer Center · Houston, Texas · NCT06065449

• Comparing surgical methods for metastatic pathologic fractures

  This study is testing which of three surgical methods works best to help people with painful fractures caused by cancer so they can feel better and move around more easily.

  Recruiting Ankara University · Ankara, altindag · NCT05825456

• Radiation therapy for bone metastases using fewer treatment sessions

  This study is testing if giving radiation therapy for bone metastases in three sessions instead of five can still help reduce pain for patients.

  Recruiting at 2 sites Kantonsspital Winterthur KSW · Winterthur, Canton of Zurich and 1 other locations · NCT05406063

• Using targeted radiation therapy for breast cancer bone metastases

  This study is testing a new type of targeted radiation therapy for people with breast cancer that has spread to their bones to see if it can help them feel better and improve their treatment outcomes.

  Recruiting Phase 1/2 Fudan University · Shanghai, Shanghai Municipality · NCT04947280

• Using Toradol for Pain Control After Prophylactic Femoral Nailing

  This study is testing whether adding Toradol to opioid pain relief can help patients recovering from surgery on their femur feel better while using fewer narcotics.

  Recruiting Phase 3 St. Louis University · St Louis, Missouri · NCT03823534

• Evaluating the best methods for reattaching hip muscles after femur replacement

  This study is testing different ways to reattach hip muscles after femur replacement surgery to see if one method helps patients recover better than others.

  Recruiting Duke University · Durham, North Carolina · NCT03261544

• Evaluation of treatments for bone metastases

  This study is testing how well standard treatments work for people with bone metastases to help improve their care and quality of life.

  Recruiting UMC Utrecht · Utrecht, Utrecht · NCT02356497

NIH-funded research (4)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Preventing and treating breast cancer spread to the brain and bones

  New brain‑penetrating drug versions and bone‑targeted drug conjugates for people with metastatic breast cancer that has spread to the brain or bones.

  NIH research University of Tennessee Health Sci Ctr · Memphis, United States · NIH-11312597

• Investigating Elacestrant for treating breast cancer that has spread to bones

  This study is looking at how a new treatment called Elacestrant works for advanced breast cancer that has spread to the bones, and it’s for patients who might want to try a new way to fight this tough condition.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11129606

• Improving treatment for brain and bone metastases in breast cancer

  This study is looking for ways to help people with metastatic breast cancer by creating new treatments that can better reach and fight cancer in the brain and bones, which could lead to improved survival and slower disease progression.

  NIH research University of Tennessee Health Sci Ctr · Memphis, United States · NIH-11059072

• Measuring metabolic activity in prostate cancer bone metastases using advanced MRI techniques

  This study is testing a new type of MRI that uses a special substance to see how well prostate cancer treatments are working in bone metastases, helping doctors spot early signs of success or resistance to therapy so they can better care for patients.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10983759

Related topics

Quick answers

How many Bone Metastases clinical trials are recruiting right now?

21, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in United States (5 trials), Italy (5 trials), China (3 trials), Slovenia (2 trials), Switzerland (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 2, Phase 2: 2, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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