Evaluation of treatments for bone metastases

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The PRESENT cohort is designed to evaluate patients with bone metastases receiving standard care while collecting clinical and patient-reported outcomes. Patients provide informed consent to participate in the cohort and may be randomly selected for future randomized controlled trials (RCTs) within the cohort. This approach allows for the identification of factors influencing treatment response and the development of survival models. The study aims to improve treatment selection and quality of life for patients suffering from painful bone metastases.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Histologic proof of malignancy;
* Radiographic or histologic proof of metastatic bone disease;
* Undergoing radiotherapy;
* Age \> 18 years;
* Informed consent - at least - for use of routinely collected clinical data.

Exclusion Criteria:

* Mentally incompetent patients;
* Life expectancy \< 1 week indicated by the treating physician.

Where it's running

• University Medical Center Utrecht
  Utrecht, Utrecht, Netherlands Recruiting

Study contacts

• Principal investigator: Helena M. Verkooijen, MD, PhD — UMC Utrecht
• Study coordinator: Roxanne Gal, PhD
• Email: r.gal@umcutrecht.nl

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Prophylactic Radiotherapy to Prevent Bone Complications in Metastatic Cancers

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• Focused high-dose SBRT for spinal tumors

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• Registry for people with symptomatic bone metastases

  This registry collects health information from adults with symptomatic bone metastases who need treatment for painful or unstable bone lesions to learn more about outcomes and care.

  Recruiting at 7 sites Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT07391410

• One-visit, simulation-free single-dose radiation for painful bone metastases

  This trial tests whether adults with one or two painful bone metastases can get pain-relieving radiation in a single visit using a simulation-free planning approach.

  Recruiting University of Utah · Salt Lake City, Utah · NCT07202273

• Dual Energy CT to Delineate Tumors and Organs at Risk in Radiotherapy

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  Recruiting at 2 sites Aalborg University Hospital · Aalborg and 2 other locations · NCT07185958

• Early radiotherapy versus observation for high‑risk painless or minimally painful bone metastases

  This will test whether giving preventive radiotherapy to people with high‑risk but painless or minimally painful bone metastases can reduce future bone complications, hospital stays, and symptoms compared with observation and usual treatment.

  Recruiting at 6 sites Cancer Research Antwerp · Wilrijk, Antwerp and 7 other locations · NCT07146074

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.