Registry for people with symptomatic bone metastases
Official title: The International Bone Metastasis Registry
Run by Memorial Sloan Kettering Cancer Center · NCT07391410 · Data updated 2026-11-12
This registry collects health information from adults with symptomatic bone metastases who need treatment for painful or unstable bone lesions to learn more about outcomes and care.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 22 Years and up |
| Sex | All |
| Enrollment | 500 (estimated) |
| Sponsor | Memorial Sloan Kettering Cancer Center Academic / other |
| Locations | 7 sites (Basking Ridge, New Jersey and 6 other locations) |
| Status | Recruiting |
| Started | January 13, 2026 |
| Main results expected | January 2031 |
| Study ends | January 2031 |
| Registry record updated | August 20, 2026 |
| Trial ID | NCT07391410 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 22 or older with biopsy-proven or clinically evident symptomatic bone metastases that require an intervention are the ideal candidates for this registry.
✕Probably not a fit
People under 22 years old, those without symptomatic lesions or not requiring intervention, and patients unable to attend participating centers are unlikely to benefit from joining this registry.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational registry enrolls adults (age ≥22) with biopsy-proven or clinically apparent symptomatic bone metastases that require an intervention. Participants receive standard clinical treatments—such as radiotherapy, cryotherapy, radiofrequency ablation, operative fixation, prosthetic replacement, or amputation—while the registry collects standardized data on symptoms, treatments, complications, and follow-up. Data are entered into a central database to capture real-world patterns of care and patient outcomes across participating centers. No experimental therapies are assigned; the dataset is intended to support future research and quality-improvement efforts.
Why it matters
Potential benefit: If successful, the registry could help clinicians identify which interventions most effectively control symptoms and reduce complications for people with bone metastases.
How similar studies have gone: Other observational registries and real-world datasets for bone metastases have provided useful insights into treatment patterns and outcomes, so this approach is established and informative rather than novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥22 years * Biopsy-proven or clinically obvious metastatic bone disease . For purposes of this study, metastatic bone disease includes skeletal involvement from multiple myeloma. * Symptomatic bone lesion requiring intervention * This includes but is not limited to radiotherapy, cryotherapy, radiofrequency ablation, operative fixation, prosthetic replacement, amputation, or any combination of the above Exclusion Criteria: * Age \<22 years
Where it's running
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Memorial Sloan Kettering Basking Ridge (All Protocol Activities)
Basking Ridge, New Jersey, United States Recruiting -
Memorial Sloan Kettering Monmouth (All Protocol Activities)
Middletown, New Jersey, United States Recruiting -
Memorial Sloan Kettering Bergen (All Protocol Activities)
Montvale, New Jersey, United States Recruiting -
Memorial Sloan Kettering Suffolk - Commack (All Protocol Activities)
Commack, New York, United States Recruiting -
Memorial Sloan Kettering Westchester (All Protocol Activities)
Harrison, New York, United States Recruiting -
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
New York, New York, United States Recruiting
Show 1 more location
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Memorial Sloan Kettering Nassau (All Protocol Activities)
Uniondale, New York, United States Recruiting
Study contacts
- Principal investigator: Jonathan Forsberg, MD, PhD — Memorial Sloan Kettering Cancer Center
- Study coordinator: Jonathan Forsberg, MD, PhD
- Email: forsbej@mskcc.org
- Phone: 212-639-2076
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Prophylactic Radiotherapy to Prevent Bone Complications in Metastatic Cancers
This study tests whether giving early radiotherapy to high-risk bone metastases, in addition to standard care, can reduce bone-related problems in adults with metastatic solid cancers.
-
Focused high-dose SBRT for spinal tumors
This program will try focused high-dose SBRT for adults with spinal metastases to track side effects and local tumor control during routine care.
-
One-visit, simulation-free single-dose radiation for painful bone metastases
This trial tests whether adults with one or two painful bone metastases can get pain-relieving radiation in a single visit using a simulation-free planning approach.
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Dual Energy CT to Delineate Tumors and Organs at Risk in Radiotherapy
This study tests whether dual-energy CT can delineate tumors and nearby critical tissues as well as MRI for patients needing radiotherapy.
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Early radiotherapy versus observation for high‑risk painless or minimally painful bone metastases
This will test whether giving preventive radiotherapy to people with high‑risk but painless or minimally painful bone metastases can reduce future bone complications, hospital stays, and symptoms compared with observation and usual treatment.
-
Analysis of surgical treatments for bone metastases in the proximal femur
This study looks at how well different surgical treatments for bone metastases in the upper thigh bone work for patients who have had fractures.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.