Clinical trial Recruiting at 1 site Observational

Comparing surgical methods for metastatic pathologic fractures

Official title: Metastatic Pathologic Fractures: Short Term Results of Endoprosthetic Reconstruction, Intramedullary Nail and Open Reduction Internal Fixation

Run by Ankara University · NCT05825456 · Data updated 2026-11-12

This study is testing which of three surgical methods works best to help people with painful fractures caused by cancer so they can feel better and move around more easily.

Quick facts

Study typeObservational
SexAll
Enrollment200 (estimated)
SponsorAnkara University
Academic / other
Drugs / interventionschemotherapy
Locations1 site (Ankara, altindag)
StatusRecruiting
StartedJanuary 1, 2022
Main results expectedJanuary 1, 2026
Study endsJanuary 1, 2026
Registry record updatedMarch 5, 2025
Trial IDNCT05825456 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include patients with metastatic pathologic fractures who are undergoing surgical intervention.

Probably not a fit

Patients with primary bone tumors or those managed conservatively will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the short-term outcomes of three surgical interventions—endoprosthetic reconstruction, intramedullary nailing, and open reduction internal fixation—for patients with metastatic pathologic fractures. Conducted at Ankara University, the study will assess factors such as the primary tumor type, chemotherapy and radiotherapy history, and various risk scores to determine the most effective surgical approach. The goal is to relieve pain and facilitate early mobilization in patients suffering from these fractures, which often require surgical intervention rather than conservative treatment.

Why it matters

Potential benefit: If successful, this study could improve surgical outcomes and quality of life for patients with metastatic pathologic fractures.

How similar studies have gone: While there have been studies on surgical interventions for metastatic fractures, this specific comparative approach is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* metastatic pathologic fracture
* operated via endoprosthesis, intramedullary nail or plate \& screws

Exclusion Criteria:

* primary bone tumor
* conservative management
* neuromuscular disease
* periprosthetic fractures
* less than 1 month follow up

Where it's running

  • Ankara University Medical Faculty
    Ankara, altindag, Turkey (Türkiye)
    Recruiting

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.