Comparing surgical methods for metastatic pathologic fractures
Metastatic Pathologic Fractures: Short Term Results of Endoprosthetic Reconstruction, Intramedullary Nail and Open Reduction Internal Fixation
Ankara University · NCT05825456
This study is testing which of three surgical methods works best to help people with painful fractures caused by cancer so they can feel better and move around more easily.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Sex | All |
| Sponsor | Ankara University (other) |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Ankara, altindag) |
| Trial ID | NCT05825456 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the short-term outcomes of three surgical interventions—endoprosthetic reconstruction, intramedullary nailing, and open reduction internal fixation—for patients with metastatic pathologic fractures. Conducted at Ankara University, the study will assess factors such as the primary tumor type, chemotherapy and radiotherapy history, and various risk scores to determine the most effective surgical approach. The goal is to relieve pain and facilitate early mobilization in patients suffering from these fractures, which often require surgical intervention rather than conservative treatment.
Who should consider this trial
Good fit: Ideal candidates include patients with metastatic pathologic fractures who are undergoing surgical intervention.
Not a fit: Patients with primary bone tumors or those managed conservatively will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve surgical outcomes and quality of life for patients with metastatic pathologic fractures.
How similar studies have performed: While there have been studies on surgical interventions for metastatic fractures, this specific comparative approach is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * metastatic pathologic fracture * operated via endoprosthesis, intramedullary nail or plate \& screws Exclusion Criteria: * primary bone tumor * conservative management * neuromuscular disease * periprosthetic fractures * less than 1 month follow up
Where this trial is running
Ankara, altindag
- Ankara University Medical Faculty — Ankara, altindag, Turkey (Türkiye) (RECRUITING)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Pathologic Fracture, Bone Metastases, Metastatic Cancer, bone metastasis, pathologic fracture, endoprosthetic reconstruction, intramedullary nailing, open reduction internal fixation