Condition

Radiation Therapy clinical trials and research

• 20Clinical trials
• 79NIH research projects
• 8Countries

Newest Radiation Therapy clinical trials

All recruiting trials (20)

• FAPI-guided radiotherapy with cadonilimab plus chemo for colorectal cancer limited to the peritoneum

  Aims to see if adding targeted radiotherapy and cadonilimab immunotherapy to standard second-line chemotherapy helps adults with colorectal cancer that’s spread only to the peritoneum.

  Recruiting Phase 3 Fudan University · Shanghai, Shanghai Municipality · NCT07815834

• Pelvic ultra-hypofractionated radiotherapy after surgery for high-risk endometrial cancer

  This trial tests whether giving 27.5 Gy in five sessions of pelvic radiotherapy after surgery is safe and feasible for high-risk endometrial cancer patients.

  Recruiting Instituto de Investigación Sanitaria Aragón · Zaragoza, Zaragoza · NCT07779109

• Radiation-related heart damage in locally advanced NSCLC tested with PET-CT

  This study tests whether PET-CT imaging with 18F-Flurpiridaz can detect early radiation-related heart damage in adults with locally advanced non-small cell lung cancer receiving standard chemoradiation.

  Recruiting Phase 2 Indiana University · Indianapolis, Indiana · NCT07761910

• Seeing what cancer patients eat during radiation treatment using a mobile food diary

  This study tests whether patients undergoing radiation therapy can consistently use a mobile food diary app to log their daily meals.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07682714

• CAIX PET/CT–guided radiation for clear cell kidney cancer

  This trial will try using CAIX-targeted PET/CT scans plus FDG PET/CT to guide focused stereotactic radiation alongside standard targeted therapy and anti‑PD‑1 immunotherapy for adults with recurrent or metastatic clear cell kidney cancer.

  Recruiting Peking University First Hospital · Beijing, Beijing Municipality · NCT07540260

• Radiation therapy options compared for newly diagnosed gynecologic cancers

  This study tests whether proton therapy works as well as conventional photon therapy for endometrial and cervical cancers.

  Recruiting at 5 sites Phase 2 University of Maryland, Baltimore · Baltimore, Maryland and 4 other locations · NCT07415681

• Virtual reality to reduce anxiety during radiation therapy

  This study will try using VR during radiation sessions to see if it reduces anxiety for adults receiving radiation for prostate, breast, lung, or head and neck cancer.

  Recruiting Wake Forest University Health Sciences · High Point, North Carolina · NCT07324577

• Node-sparing low-dose radiotherapy combined with chemotherapy and PD-1 blocker for high-risk pMMR/MSS locally advanced colon cancer.

  This trial tests whether adding node-sparing low-dose radiotherapy to standard chemotherapy and a PD-1 blocker can improve tumor response in adults with high-risk, locally advanced pMMR/MSS colon cancer before surgery.

  Recruiting Phase 2 Sixth Affiliated Hospital, Sun Yat-sen University · Guangzhou, Guangdong · NCT07279077

• Combining radiation therapy with targeted and immunotherapy for advanced kidney cancer

  This study is testing a new treatment that combines radiation therapy with two other medications to see if it helps people with advanced kidney cancer live longer without their disease getting worse.

  Recruiting Phase 2 Peking University First Hospital · Beijing, Beijing Municipality · NCT06889649

• Adjuvant chemotherapy for high-grade prostate cancer

  This study is testing if adding chemotherapy to standard treatment after radiation can help men with high-grade prostate cancer live longer without their cancer coming back.

  Recruiting at 3 sites Peking University First Hospital · Beijing, Beijing Municipality and 2 other locations · NCT06864533

• Combining targeted therapy and immunotherapy with radiation for advanced kidney cancer

  This study is testing if combining targeted therapy and immunotherapy with a specific type of radiation can help people with advanced kidney cancer live longer without their disease getting worse.

  Recruiting at 2 sites Peking University First Hospital · Beijing, Beijing Municipality and 1 other locations · NCT06583070

• Cooling device to preserve taste during radiation for head and neck cancer

  This study is testing a cooling device to see if it can help people with advanced throat cancer keep their sense of taste while they undergo radiation and chemotherapy.

  Recruiting Early Phase 1 Henry Ford Health System · Detroit, Michigan · NCT06579248

• AI-assisted contouring for breast cancer radiation treatment

  This study is testing if using AI to help outline areas for radiation treatment in breast cancer patients is just as good and faster than having doctors do it by hand.

  Recruiting at 3 sites Royal North Shore Hospital · Dubbo, New South Wales and 2 other locations · NCT06546592

• New imaging methods for detecting brain tumors in patients with metastasis

  This study is testing new imaging techniques to see if they can better detect brain tumors in patients who have cancer that has spread to the brain.

  Recruiting Phase 3 University of Wisconsin, Madison · Madison, Wisconsin · NCT06159335

• Evaluating a new device for vaginal dilation after pelvic radiation therapy

  This study is testing a new device that helps women who have had pelvic radiation therapy to safely and comfortably manage vaginal dilation and see if it improves their quality of life and reduces pelvic pain.

  Recruiting Hyivy Health Inc · Kitchener, Ontario · NCT05648253

• Radiation therapy for bone metastases using fewer treatment sessions

  This study is testing if giving radiation therapy for bone metastases in three sessions instead of five can still help reduce pain for patients.

  Recruiting at 2 sites Kantonsspital Winterthur KSW · Winterthur, Canton of Zurich and 1 other locations · NCT05406063

• Combining vertebroplasty with radiation therapy for spine metastases pain relief

  This study is testing whether combining a procedure to strengthen the spine with radiation therapy can help people with spine cancer feel less pain and lower their chances of fractures.

  Recruiting at 2 sites Centre hospitalier de l'Université de Montréal (CHUM) · Montreal, Quebec and 1 other locations · NCT05317026

• Stereotactic body radiotherapy for hormone-sensitive prostate cancer with few metastases

  This study is testing whether a special type of targeted radiation therapy combined with standard treatment can help men with hormone-sensitive prostate cancer that has spread to a few places live longer and feel better.

  Recruiting at 7 sites Umeå University · Lund, Lund and 6 other locations · NCT04983095

• Evaluating quality of life after treatment for rectal cancer

  This study looks at how treatment for rectal cancer affects the quality of life for patients who receive radiation or chemotherapy before surgery.

  Recruiting Ludwig-Maximilians - University of Munich · Munich, Bavaria · NCT03731130

• Using MRI to improve radiation therapy planning and response assessment

  This study is testing new MRI and CT imaging techniques to see if they can help cancer patients get better radiation therapy and understand how well their treatment is working.

  Recruiting at 7 sites Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT02422550

NIH-funded research (newest 40 of 79)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Protecting small blood vessels from radiation by boosting mitochondrial health

  It aims to prevent radiation-related damage to tiny blood vessels and reduce later thinking and memory problems in people who get radiation therapy by protecting cell mitochondria.

  NIH research Oklahoma City VA Medical Center · Oklahoma City, United States · NIH-11515218

• Proton SBRT for refractory ventricular tachycardia with real-time 3D/4D imaging

  A patient-facing study exploring a proton-based, noninvasive radiation therapy to treat stubborn VT using advanced 3D and 4D imaging to target the heart safely.

  NIH research University of Chicago · Chicago, United States · NIH-11455881

• Embedding symptom support in radiation therapy for prostate cancer

  A multi-site study tests whether delivering mindfulness-based symptom support right inside radiation therapy is feasible and acceptable for men with prostate cancer.

  NIH research Northwestern University · Chicago, United States · NIH-11441235

• Targeting SREBP2 to boost radiation therapy in HPV-negative head and neck cancer

  This grant aims to see if blocking SREBP2 can make radiation therapy work better for people with HPV-negative Head and Neck Squamous Cell Carcinoma.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11427724

• Genetic and Immune Factors in Squaring the Room: Sacituzumab plus Radiation for Bladder Cancer

  A study aims to understand why combining sacituzumab with radiation helps some bladder cancer patients more than others, with the goal of making bladder-sparing therapy more effective.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11416566

• CivaDerm: a new four-day skin cancer radiation bandage

  A new four‑day radiation bandage for non-melanoma skin cancer aims to treat facial and other areas without multiple clinic visits or big scars.

  NIH research Civatech Oncology, INC. · Morrisville, UNITED STATES · NIH-11408990

• Using mitochondria to protect the brain’s small vessels during radiation cancer therapy

  Aims to find ways to protect brain blood vessels from damage caused by radiation therapy used for cancer, so veterans and others can keep cognition and brain health.

  NIH research Oklahoma City VA Medical Center · Oklahoma City, United States · NIH-11399494

• PET marker to map brain synapses after radiation therapy

  A new PET imaging test uses a special tracer to watch how synapses in the brain change after radiation therapy, aiming to understand and protect cognitive function in people affected by CNS tumors.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11397465

• Surgery versus focused stereotactic radiation for early-stage lung cancer

  This project compares surgery and focused stereotactic radiation (SBRT) for people with stage I non-small cell lung cancer to learn which approach best balances cure, side effects, and recovery.

  NIH research Washington University · Saint Louis, United States · NIH-11380728

• A smarter radiomics tool to predict lymph node cancer spread for targeted neck cancer radiation

  A new radiomics model uses imaging data to predict which cervical lymph nodes are cancerous so doctors can tailor radiation therapy for head and neck cancer.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11372242

• Targeting ATM to Make Radiation More Effective in Brain Stem Glioma

  A specialized program at Duke University aims to help people with brainstem glioma improve how well radiation works by turning off a key DNA damage sensor called ATM.

  NIH research Duke University · Durham, United States · NIH-11372236

• Personalized radiation targeting for glioblastoma using brain pathway maps and tumor biomarkers

  This project combines special MRI brain pathway images and tumor molecular markers to create more personalized radiation targets for people with glioblastoma.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11371823

• Targeting tumor survival signals to improve radiation response in pancreatic cancer

  This grant tests a new approach to make pancreatic cancer tumors more sensitive to radiation, aiming to help patients with locally advanced disease become eligible for surgery or experience better disease control.

  NIH research Washington University · Saint Louis, United States · NIH-11365872

• Improve brain tumor radiation planning with high-resolution MR spectroscopy

  Aims to use advanced MR spectroscopy imaging to more precisely target glioma tumors during radiation therapy.

  NIH research Yale University · New Haven, United States · NIH-11360705

• A MRI-based method to track tumor oxygen levels during radiation therapy

  Researchers are testing MRI-based ways to monitor oxygen in tumors during radiation treatment to tailor doses and improve outcomes for cancer patients.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11344793

• Planning safer electron FLASH radiation treatments

  This project builds computer tools to help doctors plan electron FLASH radiation that may better protect healthy tissue for people needing high‑dose radiotherapy.

  NIH research University of Missouri-Columbia · Columbia, United States · NIH-11319868

• Real-time, in-vivo dosimetry for safe FLASH radiation therapy in breast cancer

  A real-time, safety-focused monitoring system using ultra-fast detectors to protect patients during FLASH radiation therapy for breast cancer.

  NIH research Blue Physics LLC · Lutz, United States · NIH-11313733

• Whole-brain metabolic MRI to guide brain tumor radiation

  This project uses a special whole-brain MRI that maps tumor chemistry to help doctors target radiation more precisely for adults with brain tumors.

  NIH research Emory University · Atlanta, United States · NIH-11306688

• AI tools to improve checks of radiation therapy plans

  Using artificial intelligence to speed up and strengthen safety checks of radiation treatment plans for people getting external beam radiotherapy.

  NIH research Stanford University · Stanford, United States · NIH-11289312

• Exploring a new way to deliver radiation therapy that minimizes damage to healthy tissues.

  This study is exploring a new type of radiation therapy called FLASH radiotherapy, which gives a quick burst of high radiation to help treat tumors while causing less harm to healthy tissues, with the hope of making cancer treatments safer and more effective for patients like you.

  NIH research University of Missouri-Columbia · Columbia, United States · NIH-11287489

• Targeted Internal Radiation and Immune Therapy for Non-Muscle-Invasive Bladder Cancer

  Aims to help people with early bladder cancer that doesn’t respond to current therapy by using a novel intravesical treatment that combines targeted radiation, immune checkpoint inhibitors, and oncolytic virus to trigger a strong anti-cancer response.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-11280102

• Radiation therapy and lung health: how radiation affects airways, blood vessels, and breathing

  This grant looks at how radiation therapy for non-small cell lung cancer can affect the lungs’ airways and blood vessels and what that means for breathing and lung function.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11279313

• Blocking NRF2 to help radiation work better for head and neck cancer

  Trying drugs that block a protein called NRF2 to help radiation therapy work better for people with head and neck squamous cell carcinoma.

  NIH research Washington University · Saint Louis, United States · NIH-11249676

• Predicting radiation-related heart damage with patient stem cells

  Using stem cells made from people who had cancer, researchers seek to understand why some patients' hearts are harmed by radiation and to find existing drugs that might protect them.

  NIH research Stanford University · Stanford, United States · NIH-11231257

• Developing a new detector system for ultra-rapid radiation therapy

  This study is working on a new type of detector to help doctors measure a fast radiation treatment called FLASH therapy, which aims to treat tumors while protecting healthy tissue, making radiation therapy safer and more effective for patients.

  NIH research Standard Imaging, INC. · Middleton, United States · NIH-11210772

• Personalized scheduling for radiation therapy in head and neck cancer

  This study is looking at how to make radiation therapy better for people with head and neck cancers by creating personalized treatment plans that adjust based on how the tumor changes during treatment, helping to reduce side effects and improve results.

  NIH research Rice University · Houston, United States · NIH-11199085

• Personalized treatment planning for head and neck cancer radiation therapy

  This study is working to make radiation therapy better for people with head and neck cancers by creating personalized treatment plans that adjust to changes in their bodies during treatment, helping to reduce side effects and protect healthy tissues.

  NIH research Rice University · Houston, United States · NIH-11198078

• Olaparib and durvalumab with radiation after first-line chemotherapy for locally advanced pancreatic cancer

  This trial tests whether adding the oral drug olaparib and the immunotherapy durvalumab to radiation can help people with locally advanced, unresectable pancreatic cancer after first-line chemotherapy.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11197961

• Personalizing proton versus conventional (photon) radiation using each patient's clinical and biological information

  This project will use patients' clinical details and biological markers to choose whether proton or standard X‑ray (photon) radiation is likely to work best with fewer side effects.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11184353

• Imaging synapse loss after brain radiation

  Using a new PET scan tracer to look for synapse changes after brain radiation therapy for people treated for central nervous system tumors.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11181525

• Clearer cone‑beam CT images for better visualization during radiation treatment

  This project tries a new two‑dimensional anti‑scatter grid to make cone‑beam CT scans clearer for people having radiation therapy for cancer.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11179179

• Real-time imaging of radiation dose inside the body

  This project will use tiny sound waves made by X‑rays to image and track the radiation dose delivered to people getting radiation therapy for cancer.

  NIH research University of California-Irvine · Irvine, United States · NIH-11178117

• Improving radiation for cervical cancer by targeting glutamine use

  This project aims to see whether blocking cancer cells' use of glutamine helps radiation control cervical cancer better.

  NIH research Washington University · Saint Louis, United States · NIH-11162381

• How genetics and the immune system affect sacituzumab plus radiation for bladder cancer

  This work looks at whether adding the antibody-drug sacituzumab to radiation helps people with muscle-invasive bladder cancer and which genetic or immune factors change that response.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11135444

• Better Radiation Therapy for Brain Tumors Using Advanced Imaging

  This work aims to make radiation therapy for brain tumors more precise by using a special type of MRI to see tumor boundaries more clearly.

  NIH research Yale University · New Haven, United States · NIH-11134536

• Better Radiation Planning for Head and Neck Cancer

  This work aims to use advanced imaging to accurately find cancer in lymph nodes for people with head and neck cancer, helping doctors target radiation more precisely.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11128695

• Protecting tiny blood vessels from radiation by supporting mitochondria

  Researchers are looking for ways to protect small blood vessels and brain function in people who get radiation therapy by helping cells' mitochondria work better.

  NIH research Iowa City VA Medical Center · Iowa City, United States · NIH-11126563

• Advanced MRI to Track Prostate Cancer Treatment

  This research explores a new type of MRI scan to see how prostate cancer responds to radiation therapy.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11124018

• Better MRI for prostate cancer radiation treatment

  This project aims to create a new MRI tool to precisely locate prostate cancer tumors, helping doctors target radiation therapy more effectively.

  NIH research Beckman Research Institute/city of Hope · Duarte, United States · NIH-11114060

• Understanding NF-kB to Improve Radiation Treatment for Cancer

  This research explores a new way to make radiation therapy more effective for cancer patients by focusing on how the body's immune system responds to treatment.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11103273

Related topics

Quick answers

How many Radiation Therapy clinical trials are recruiting right now?

20, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in United States (7 trials), China (6 trials), Canada (2 trials), Sweden (1 trial), Germany (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 3: 2, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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