Biocompatible coating to improve aneurysm devices
Official title: Development of a novel biocompatible polymer coating for aneurysm treatment devices
Funded at Aneuvas Technologies, INC. · NIH-11316546 · Data updated 2026-11-12
A new biocompatible polymer coating for aneurysm treatment devices is being developed to reduce clotting and improve healing without heavy drug therapy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Aneuvas Technologies, INC. NIH-funded |
| Lab location | 1 site (Flagstaff, UNITED STATES) |
| Project start | September 4, 2026 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $435,979 |
| NIH project number | 1R41NS143513-01A1 |
| Project ID | NIH-11316546 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults with intracranial aneurysms who are treated with endovascular devices and are eligible for device coatings.
✕Less likely to help
Patients not receiving endovascular aneurysm treatment or those with contraindications to device implants may not benefit.
What this research studies
This project aims to coat nitinol-based aneurysm devices with a polymer material that is safer and more compatible with the body. The team will refine coating methods to ensure durable, non-thrombogenic surfaces that support tissue regrowth. By focusing on surface modifications and nano-scale treatments, they hope to improve endothelial healing and reduce recurrence after device placement. The work builds on prior findings about PPODA-QT coatings and intends to apply them to flow diverters used in patients with brain aneurysms.
Why it matters
Potential benefit: If successful, patients could experience safer aneurysm treatment with fewer blood-thinning medications and lower risk of device-related complications.
How similar studies have gone: Previous studies showed promising biocompatible coatings, but this project extends coating to nitinol flow diverters and human-use devices.
Where this research is happening
-
Aneuvas Technologies, INC.
Flagstaff, United States Active
Researchers
- Principal investigator: Becker, Timothy Andrew — Aneuvas Technologies, INC.
- Study coordinator: Becker, Timothy Andrew
Related research
Other NIH-funded projects on the same topics.
-
WARRIORS: Should women with small abdominal aortic aneurysms get early repair or stay under surveillance?
A large international study is testing whether women with small abdominal aortic aneurysms should have early repair or watchful waiting, to see if earlier treatment improves survival and quality of life.
-
Biomarker clues from animal and computer models to predict when the ascending aorta could fail
Researchers will combine animal studies and computer models to find biological clues that help predict dangerous changes in the ascending aorta for people with aortic aneurysm.
-
How the small regulator miR-146a affects abdominal aortic aneurysm
This project aims to see if boosting a natural genetic regulator called miR-146a can help slow or prevent growth and rupture of abdominal aortic aneurysms in people with this condition.
-
MOF’s role in weakening the aorta and stopping aneurysm growth
Scientists are studying how a molecule called MOF and inflammatory signals affect abdominal aortic aneurysms to find ways to slow or stop their enlargement.
-
WARRIORS: Early repair or observation for women with small abdominal aortic aneurysms
This research test asks whether women with small, asymptomatic abdominal aortic aneurysms should have early repair or continued surveillance to improve survival and quality of life.
-
Endovascular Suturing Device to Improve Endograft Fixation in Abdominal Aortic Aneurysm
A new device aims to better secure endografts during EVAR for abdominal aortic aneurysm to reduce future repairs.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.