Modeling clotting and blood flow in brain aneurysm treatment
Official title: Computational modeling of platelets and thrombosis in cerebral aneurysm treatment
Funded at University of Washington · NIH-11146635 · Data updated 2026-11-12
This project uses computer models of blood flow and platelets to predict clotting and treatment outcomes for people treated for brain aneurysms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | January 1, 2018 |
| Project end | July 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $415,433 |
| NIH project number | 5R01NS105692-08 |
| Project ID | NIH-11146635 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with a diagnosed cerebral (brain) aneurysm who are scheduled for, undergoing, or have recently undergone aneurysm treatment and can share their medical imaging and treatment records.
✕Less likely to help
People without brain aneurysms or whose care does not include shareable imaging or treatment data are unlikely to directly benefit from this project.
What this research studies
You would have your scans and treatment information used to build a personalized computer model that combines blood-flow patterns with tracking of platelets to capture clotting behavior inside treated aneurysms. The team adds measures like how long platelets stay in the aneurysm and the forces they experience to create more complete simulations before and after repair. They compare those model predictions with real treatment outcomes to find patterns linked to aneurysm recurrence or need for retreatment. If this works, the models could help doctors pick treatments that lower the chance of retreatment or bleeding for patients like you.
Why it matters
Potential benefit: Could help doctors predict which patients are likely to form clots or have treatment failure after aneurysm repair, supporting better treatment choices.
How similar studies have gone: Previous blood-flow (CFD) approaches have produced mixed results, while adding platelet-tracking (Lagrangian) measures is a newer approach that shows promise but is not yet proven.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Levitt, Michael Robert — University of Washington
- Study coordinator: Levitt, Michael Robert
Related research
Other NIH-funded projects on the same topics.
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Computational modeling of platelets and blood flow to predict cerebral aneurysm treatment outcomes
A researchers at UW are using computer models of blood flow and platelets to better predict whether an aneurysm treatment will work.
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Improving predictions for treating cerebral aneurysms using computer models
This study is working to improve computer models that help doctors understand blood flow and how platelets behave in brain aneurysms, so they can better predict how well treatments will work for patients like you.
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Improving predictions for treating cerebral aneurysms using computer models
This study is looking to improve computer models that help doctors understand blood flow and how platelets behave in brain aneurysms, so they can better predict how well treatments will work for patients like you.
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Investigating how certain proteins in blood contribute to blood clots and aortic aneurysms
This study is looking at a protein called RIP3 in blood samples from people with aortic aneurysms to see how it affects blood clotting and could help us find new ways to treat this condition.
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Role of blood flow mechanics and transfusion in sepsis-related tiny-cl vessel clots
A patient-focused look at how red blood cell flow and transfusions might influence tiny blood vessel clots and organ problems in sepsis.
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WARRIORS: Should women with small abdominal aortic aneurysms get early repair or stay under surveillance?
A large international study is testing whether women with small abdominal aortic aneurysms should have early repair or watchful waiting, to see if earlier treatment improves survival and quality of life.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.