Modeling clotting and blood flow in brain aneurysm treatment
Computational modeling of platelets and thrombosis in cerebral aneurysm treatment
['FUNDING_R01'] · UNIVERSITY OF WASHINGTON · NIH-11146635
This project uses computer models of blood flow and platelets to predict clotting and treatment outcomes for people treated for brain aneurysms.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11146635 on ClinicalTrials.gov |
What this research studies
You would have your scans and treatment information used to build a personalized computer model that combines blood-flow patterns with tracking of platelets to capture clotting behavior inside treated aneurysms. The team adds measures like how long platelets stay in the aneurysm and the forces they experience to create more complete simulations before and after repair. They compare those model predictions with real treatment outcomes to find patterns linked to aneurysm recurrence or need for retreatment. If this works, the models could help doctors pick treatments that lower the chance of retreatment or bleeding for patients like you.
Who could benefit from this research
Good fit: People with a diagnosed cerebral (brain) aneurysm who are scheduled for, undergoing, or have recently undergone aneurysm treatment and can share their medical imaging and treatment records.
Not a fit: People without brain aneurysms or whose care does not include shareable imaging or treatment data are unlikely to directly benefit from this project.
Why it matters
Potential benefit: Could help doctors predict which patients are likely to form clots or have treatment failure after aneurysm repair, supporting better treatment choices.
How similar studies have performed: Previous blood-flow (CFD) approaches have produced mixed results, while adding platelet-tracking (Lagrangian) measures is a newer approach that shows promise but is not yet proven.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEVITT, MICHAEL ROBERT — UNIVERSITY OF WASHINGTON
- Study coordinator: LEVITT, MICHAEL ROBERT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.