Collection of data and samples linked to the French Register of Intracranial Aneurysms
Multimodal Biocollection Linked to the French Register of Intracranial Aneurysms
This study is trying to gather information and samples to help understand different types of brain aneurysms and see if genetics can help predict their risk of bursting.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 1100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Nantes University Hospital Academic / other |
| Locations | 2 sites (Nantes, Loire-Atlantique and 1 other locations) |
| Trial ID | NCT06689410 on ClinicalTrials.gov |
What this trial studies
The bCAN initiative aims to create a comprehensive collection of multimodal data and human samples associated with the French Intracranial Aneurysm Registry. This project focuses on developing a predictive model for intracranial aneurysm phenotypes by integrating genetic, imaging, and clinical data. It seeks to enhance risk stratification for ruptured intracranial aneurysms by identifying specific subgroups based on genetic and phenotypic characteristics. The study will also explore the relationships between genotypes and phenotypes in both sporadic and familial cases of intracranial aneurysms.
Who should consider this trial
Good fit: Ideal candidates include adults with a confirmed diagnosis of bifurcation intracranial aneurysms, either sporadic or familial.
Not a fit: Patients with aneurysms that are not typical bifurcation types or those who do not meet the inclusion criteria may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic and prognostic strategies for patients with intracranial aneurysms.
How similar studies have performed: Other studies have shown promise in using multimodal data approaches for understanding intracranial aneurysms, but this specific methodology is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria for sporadic ICA cases: * Any adult patient consulting for a definite and typical bifurcation AIC authenticated on MRI and/or cerebral arteriography * Aneurysm discovered less than a year ago, with initial imaging (MRI and/or CTA and DSA) available * Written consent obtained for study participation * Patient covered by a social security plan Inclusion criteria for index and related cases (familial forms) of intracranial aneurysms (ICA): * Index case: Any adult patient consulting for a definite and typical bifurcation ICA presenting at least one other case with ICA related (child, parent, brother, sister) detected by MRI with at least one Time of Flight (TOF) sequence. * Family relatives: children, parents, brothers, sisters, of legal age, of patients with a family history of definite, typical bifurcation AIC (≥ 4 affected), Screening to be performed using MRI with at least a Time of Flight (TOF) sequence. * Written consent to participate in the study * Patient and relatives covered by a social security plan Exclusion Criteria: * Syndromic diagnosis known to cause ICA: Marfan syndrome, OSA with SMAD 3, Elhers Danlos syndrome type II and IV, Autosomal Dominant Cystic Fibrosis, Moya-Moya syndrome * AIC with : Dissecting or fusiform, Associated with arteriovenous malformation, Blister-like, Mycotic * Cerebral white matter pathology detected on MRI evoking : Col4a1 mutation * Patient under guardianship or conservatorship * Person under court protection * Contraindication to an MRI scan
Where this trial is running
Nantes, Loire-Atlantique and 1 other locations
- Nantes University Hospital — Nantes, Loire-Atlantique, France (Recruiting)
- CHU Clermont-Ferrand — Clermont-Ferrand, France (Recruiting)
Study contacts
- Principal investigator: Romain BOURCIER, MD — Nantes University Hospital
- Study coordinator: Romain BOURCIER, MD
- Email: romain.bourcier@chu-nantes.fr
- Phone: 33240165608
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.