Collection of data and samples linked to the French Register of Intracranial Aneurysms

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The bCAN initiative aims to create a comprehensive collection of multimodal data and human samples associated with the French Intracranial Aneurysm Registry. This project focuses on developing a predictive model for intracranial aneurysm phenotypes by integrating genetic, imaging, and clinical data. It seeks to enhance risk stratification for ruptured intracranial aneurysms by identifying specific subgroups based on genetic and phenotypic characteristics. The study will also explore the relationships between genotypes and phenotypes in both sporadic and familial cases of intracranial aneurysms.

Why it matters

Who can join: the full rules

Inclusion criteria for sporadic ICA cases:

* Any adult patient consulting for a definite and typical bifurcation AIC authenticated on MRI and/or cerebral arteriography
* Aneurysm discovered less than a year ago, with initial imaging (MRI and/or CTA and DSA) available
* Written consent obtained for study participation
* Patient covered by a social security plan

Inclusion criteria for index and related cases (familial forms) of intracranial aneurysms (ICA):

* Index case: Any adult patient consulting for a definite and typical bifurcation ICA presenting at least one other case with ICA related (child, parent, brother, sister) detected by MRI with at least one Time of Flight (TOF) sequence.
* Family relatives: children, parents, brothers, sisters, of legal age, of patients with a family history of definite, typical bifurcation AIC (≥ 4 affected), Screening to be performed using MRI with at least a Time of Flight (TOF) sequence.
* Written consent to participate in the study
* Patient and relatives covered by a social security plan

Exclusion Criteria:

* Syndromic diagnosis known to cause ICA: Marfan syndrome, OSA with SMAD 3, Elhers Danlos syndrome type II and IV, Autosomal Dominant Cystic Fibrosis, Moya-Moya syndrome
* AIC with : Dissecting or fusiform, Associated with arteriovenous malformation, Blister-like, Mycotic
* Cerebral white matter pathology detected on MRI evoking : Col4a1 mutation
* Patient under guardianship or conservatorship
* Person under court protection
* Contraindication to an MRI scan

Where it's running

• Nantes University Hospital
  Nantes, Loire-Atlantique, France Recruiting
• CHU Bordeaux Hôpital Pellegrin
  Bordeaux, France Recruiting
• CHU de Brest
  Brest, France Recruiting
• CHU Caen-Normandie
  Caen, France Recruiting
• CHU Clermont-Ferrand
  Clermont-Ferrand, France Recruiting
• CHRU de Nancy
  Nancy, France Recruiting

Study contacts

• Principal investigator: Romain BOURCIER, MD — Nantes University Hospital
• Study coordinator: Romain BOURCIER, MD
• Email: romain.bourcier@chu-nantes.fr
• Phone: 33240165608

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.