Condition

Amblyopia clinical trials and research

• 25Clinical trials
• 9NIH research projects
• 1New in 30 days
• 7Countries

Newest Amblyopia clinical trials

All recruiting trials (25)

• Psilocybin-assisted therapy to help adults with amblyopia see more clearly

  This study tests whether a single or small doses of psilocybin can boost the effectiveness of amblyopia treatment in adults.

  Recruiting Phase 1/2 Johns Hopkins University · Baltimore, Maryland · NCT07920081

• Augmented Reality Binocular Therapy for Adult Amblyopia

  This trial tests a home-based augmented reality binocular therapy to see if it improves vision in adults 18–40 with anisometropic amblyopia, compared with placebo training.

  Recruiting at 2 sites Polytechnic Institute of Porto · Coimbra, Coimbra District and 1 other locations · NCT07819552

• Gabor-based visual training for adults with amblyopia

  This study tests a computer-based Gabor training program to see if it can improve vision in adults aged 18–39 with amblyopia due to anisometropia or strabismus.

  Recruiting Shanghai Eye Disease Prevention and Treatment Center · Shanghai · NCT07764198

• Noninvasive brain stimulation plus augmented reality vision therapy for anisometropic amblyopia in adults

  This trial tests whether adding HD-tDCS to AR-based dichoptic therapy can improve vision in adults with anisometropic amblyopia.

  Recruiting at 2 sites Polytechnic Institute of Porto · Coimbra, Coimbra District and 1 other locations · NCT07752433

• tDCS for paediatric amblyopia

  This study tests whether non-invasive brain stimulation (tDCS) can improve vision for children aged 4–14 with amblyopia who didn’t get enough help from patching.

  Recruiting Universidad de Murcia · Murcia · NCT07547670

• Gamified visual training with occlusion for kids with anisometropic amblyopia

  This trial tests two kid-friendly digital games plus patching to see if they improve vision and motivation in children aged 4–7 with anisometropic amblyopia compared with patching alone.

  Recruiting Xinhua Hospital, Shanghai Jiao Tong University School of Medicine · Shanghai, Shanghai Municipality · NCT07472231

• Combined fluoxetine and patching to improve and maintain vision in amblyopia using OCTA and VEP

  This project will test whether adding fluoxetine to standard eye patching helps improve and maintain vision in people over 10 with amblyopia.

  Recruiting Minia University · Minya, Minya Governorate · NCT07417046

• AmblyoFix for one-eye (unilateral) amblyopia in children 7–12 years

  This will test whether AmblyoFix, an at-home binocular digital therapy, can improve the weaker eye's vision in children aged 7–12 with unilateral amblyopia compared with past patching treatment.

  Recruiting Eyesight Electronics · Cairo · NCT07323953

• At-home Curesight treatment for children 8 to 12 with amblyopia

  This will test whether at-home Curesight dichoptic video therapy can improve vision in children aged 8–12 with amblyopia.

  Recruiting Retina Foundation of the Southwest · Dallas, Texas · NCT07281742

• Valproate to Help Residual Amblyopia in Kids 8-17

  This trial tests whether adding valproate to standard patching can improve vision in children and teens with residual amblyopia beyond the normal treatment window.

  Recruiting Phase 1/2 Boston Children's Hospital · Boston, Massachusetts · NCT07226141

• Examining eye conditions in patients with craniosynostosis

  This study looks at the eye problems that can happen in people with craniosynostosis to better understand their eye health and improve their care.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT06928727

• Treatment of amblyopia in older adolescents using brain stimulation

  This study is testing if a brain stimulation treatment can help older teens and young adults with amblyopia see better.

  Recruiting Tianjin Eye Hospital · Tianjin, Tianjin Municipality · NCT06760910

• Noninvasive brain stimulation for treating amblyopia in adults

  This study is testing a new non-invasive brain stimulation method to see if it can help adults with amblyopia improve their vision.

  Recruiting Midwestern University · Downers Grove, Illinois · NCT06712849

• Dichoptic treatment for amblyopia in children aged 8 to 12

  This study is testing two new treatments for lazy eye in kids aged 8 to 12 to see if they can improve their vision better than just wearing glasses.

  Recruiting at 58 sites Phase 3 Jaeb Center for Health Research · Birmingham, Alabama and 57 other locations · NCT06524882

• Registry of Amblyopia Patients Using Luminopia Treatment

  This study is looking at how well the Luminopia treatment works for people with amblyopia by collecting real-world experiences from patients and their eye doctors over at least 12 weeks.

  Recruiting at 13 sites Luminopia · San Ramon, California and 12 other locations · NCT06429280

• Dichoptic treatment for amblyopia in young children

  This study is testing a new headset treatment for lazy eye in kids aged 4 to 7 to see if it works better than the usual patching method.

  Recruiting at 73 sites Phase 3 Jaeb Center for Health Research · Birmingham, Alabama and 72 other locations · NCT06380517

• Exploring treatments for amblyopia in children using OCT technology

  This study is testing different treatments for amblyopia in children aged 4-16 to see how well they improve vision using eye patches and foveation therapy.

  Recruiting State University of New York College of Optometry · New York, New York · NCT05714449

• Observing blood biomarkers in children with amblyopia

  This study looks at blood samples from children with amblyopia to see if certain markers can help predict how well their treatment will work.

  Recruiting Zhongshan Ophthalmic Center, Sun Yat-sen University · Guangzhou, Guangdong · NCT05705778

• New treatment approaches for amblyopia using video games and perceptual learning

  This study is testing whether playing special video games can help improve vision in people with amblyopia, both kids and adults.

  Recruiting Nova Southeastern University · Fort Lauderdale, Florida · NCT05522972

• Comparing patch-free therapy to traditional patching for amblyopia in children

  This study is testing if a new patch-free therapy works better than traditional patching for treating amblyopia in young children.

  Recruiting Retina Foundation of the Southwest · Dallas, Texas · NCT05440448

• Viewing movies as treatment for amblyopia in children

  This study is testing if watching special movies can help young children with amblyopia see better compared to using a patch on their eye.

  Recruiting Retina Foundation of the Southwest · Dallas, Texas · NCT05439200

• Comparing two methods of treating amblyopia in children

  This study is testing which treatment method works better for kids with amblyopia by comparing wearing glasses and patching at the same time versus wearing glasses first and then patching if needed.

  Recruiting at 68 sites Phase 3 Jaeb Center for Health Research · Birmingham, Alabama and 67 other locations · NCT04378790

• Examining visual function in children with amblyopia and strabismus during treatment

  This study is testing how different treatments for amblyopia and strabismus, like patching and glasses, can improve vision in children by checking their eye movements and clarity before and after treatment.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT04310241

• Using video games and binocular therapy to treat lazy eye in children

  This study is testing if using video games and special glasses can help children with lazy eye see better compared to traditional eye patching.

  Recruiting Universidad Autonoma de Nuevo Leon · Monterrey, Nuevo León · NCT03655912

• Enhanced treatment for amblyopia using binocular games

  This study is testing if playing special games for 8 weeks can help children aged 4-10 with amblyopia see better compared to the usual 4-week treatment.

  Recruiting Retina Foundation of the Southwest · Dallas, Texas · NCT03288948

NIH-funded research (9)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• High-resolution 7T fMRI to understand developmental causes of amblyopia

  This project uses ultra-high field brain imaging to learn how amblyopia develops in people, with an emphasis on how vision sources interact in early life.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11445359

• A smart occlusion dose monitor to help kids with amblyopia wear patches

  A new device called AmblyoGo helps children with amblyopia wear their eye patches more consistently by automatically tracking patch wear and sharing simple feedback with families and clinicians.

  NIH research Edge Eye Labs INC. · San Francisco, United States · NIH-11410213

• Better treatments for amblyopia (lazy eye) and binocular vision in children

  This compares a patch-free, activity-based therapy to standard eye patching to help children with amblyopia (lazy eye) improve vision and stick with treatment.

  NIH research Retina Foundation of the Southwest · Dallas, United States · NIH-11285476

• How attention can change eye suppression in amblyopia (lazy eye)

  This project tests whether directing attention to the weaker eye can reduce visual suppression for adults with amblyopia (lazy eye).

  NIH research Smith-Kettlewell Eye Research Institute · San Francisco, United States · NIH-11285207

• Understanding how attention affects vision in lazy eye

  This study is looking at how focusing your attention can help improve vision in adults with lazy eye, and it aims to find new ways to treat this condition by understanding how the brain works in these situations.

  NIH research Smith-Kettlewell Eye Research Institute · San Francisco, United States · NIH-11030313

• Investigating visual perception issues in children with amblyopia

  This study is looking at how kids with anisometropic amblyopia see things differently, especially when it comes to recognizing patterns and contrasts, and it aims to learn more about their vision challenges through fun visual tests and advanced imaging techniques.

  NIH research Boston Children's Hospital · Boston, United States · NIH-10909973

• Understanding depth perception in individuals with lazy eye

  This study is looking at how people with lazy eye see depth and if their side vision plays a role in that, with the goal of finding better ways to help improve their vision.

  NIH research Smith-Kettlewell Eye Research Institute · San Francisco, United States · NIH-10898776

• Understanding vision problems in amblyopia and their brain basis

  This study is looking into how amblyopia affects the way people see things, especially how their brains understand different directions, to help find better ways to treat this common vision issue.

  NIH research State College of Optometry · New York, United States · NIH-10843859

• Using advanced brain imaging to understand visual impairments in amblyopia

  This study is looking at how amblyopia, or lazy eye, impacts the way the brain works, using advanced imaging technology to better understand the visual problems it causes, with the goal of finding better ways to diagnose and treat people with this condition.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10808083

Related topics

Quick answers

How many Amblyopia clinical trials are recruiting right now?

25, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in United States (14 trials), China (4 trials), Portugal (2 trials), Egypt (2 trials), Spain (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 3, Phase 1/2: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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