Noninvasive brain stimulation for treating amblyopia in adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of non-invasive brain stimulation, specifically high-frequency transcranial random noise stimulation, in treating adults with amblyopia. Participants will be randomly assigned to receive either active stimulation or sham stimulation over five consecutive days. The study aims to assess the impact of this intervention on neuronal plasticity in the visual cortex and its effects on visual perception and function. Researchers will measure various visual acuity parameters to evaluate the outcomes of the treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults between 18 and 55 years of age
* Formal diagnosis of amblyopia in one or both eyes of any etiology

Exclusion Criteria:

* History of optic nerve disease, including glaucoma and optic neuritis
* History of neurological conditions, including demyelinating disease or stroke
* Presence of metal or electronic implants in or on the body, including pacemakers
* Taking medications that can affect normal neurological function, including antipsychotics, antiepileptics, and opioids

Where it's running

• Midwestern University Eye Institute
  Downers Grove, Illinois, United States Recruiting

Study contacts

• Study coordinator: Arijit Chakraborty, PhD
• Email: achakr@midwestern.edu
• Phone: 630-960-3172

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Psilocybin-assisted therapy to help adults with amblyopia see more clearly

  This study tests whether a single or small doses of psilocybin can boost the effectiveness of amblyopia treatment in adults.

  Recruiting Phase 1/2 Johns Hopkins University · Baltimore, Maryland · NCT07920081

• Augmented Reality Binocular Therapy for Adult Amblyopia

  This trial tests a home-based augmented reality binocular therapy to see if it improves vision in adults 18–40 with anisometropic amblyopia, compared with placebo training.

  Recruiting at 2 sites Polytechnic Institute of Porto · Coimbra, Coimbra District and 1 other locations · NCT07819552

• Gabor-based visual training for adults with amblyopia

  This study tests a computer-based Gabor training program to see if it can improve vision in adults aged 18–39 with amblyopia due to anisometropia or strabismus.

  Recruiting Shanghai Eye Disease Prevention and Treatment Center · Shanghai · NCT07764198

• Noninvasive brain stimulation plus augmented reality vision therapy for anisometropic amblyopia in adults

  This trial tests whether adding HD-tDCS to AR-based dichoptic therapy can improve vision in adults with anisometropic amblyopia.

  Recruiting at 2 sites Polytechnic Institute of Porto · Coimbra, Coimbra District and 1 other locations · NCT07752433

• tDCS for paediatric amblyopia

  This study tests whether non-invasive brain stimulation (tDCS) can improve vision for children aged 4–14 with amblyopia who didn’t get enough help from patching.

  Recruiting Universidad de Murcia · Murcia · NCT07547670

• Gamified visual training with occlusion for kids with anisometropic amblyopia

  This trial tests two kid-friendly digital games plus patching to see if they improve vision and motivation in children aged 4–7 with anisometropic amblyopia compared with patching alone.

  Recruiting Xinhua Hospital, Shanghai Jiao Tong University School of Medicine · Shanghai, Shanghai Municipality · NCT07472231

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.