Treatment of amblyopia in older adolescents using brain stimulation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of transcranial direct current stimulation (tDCS) in improving visual outcomes for older adolescents with amblyopia. Participants aged 10-30 will be randomly assigned to receive either active tDCS or sham stimulation over a period of six months. The study will assess changes in visual acuity and brain activity using functional MRI before and after the treatment. The goal is to determine if tDCS can enhance visual cortex plasticity and improve vision in individuals with amblyopia.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Children and their legal guardians have obtained consent in writing.
* Participants aged 10-30, of any gender.
* Participants must meet the diagnostic criteria for amblyopia: unilateral amblyopia with a difference of two lines or more in visual acuity between the eyes, or bilateral amblyopia with best-corrected visual acuity worse than 20/30 (or worse than 0.2 logMAR). The visual acuity charts to be used are LEA SYMBOLS® (Good-Lite Co., Elgin, IL) or HOTV visual acuity chart.

Exclusion Criteria:

* Participants who may have eye diseases affecting vision or refractive errors (such as cataracts, crystalline lens damage, glaucoma, macular degeneration, corneal disorders, retinitis pigmentosa, retinal detachment, severe vitreous opacities, etc
* History of eye trauma or intraocular surgery
* Inability to cooperate with examinations
* Presence of concomitant systemic diseases (such as epilepsy)
* Participation in any other experimental treatment within the past 3 months
* Other situations deemed unsuitable by the investigator.

Where it's running

• Tianjin Eye Hospital
  Tianjin, Tianjin Municipality, China Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.