Augmented Reality Binocular Therapy for Adult Amblyopia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with anisometropic amblyopia will use a mixed-reality headset at home to perform binocular visual training designed to encourage both eyes to contribute. Participants are randomly assigned to active AR binocular therapy or placebo AR visual training, with the same device used in both groups. The study will assess improvements in visual acuity, binocular function, and potential changes in retinal and brain function, plus whether gains persist at 6 months post-treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age between 18 and 40 years.
* Diagnosis of anisometropic amblyopia, defined as unilateral amblyopia with an interocular difference of at least 2 lines in best-corrected visual acuity (BCVA), with BCVA worse than 20/32 in the more affected eye.

Exclusion Criteria:

* Amblyopia other than anisometropic amblyopia.
* Bilateral amblyopia.
* Ophthalmologic or neuro-ophthalmologic disease other than amblyopia.
* Neurological disease, chronic pharmacological therapy, or implanted medical devices.
* Any ocular surgery or ocular treatment within the previous year.
* Significant media opacities that may prevent fundus examination.
* Inability to provide informed consent.

Where it's running

• Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), University of Coimbra
  Coimbra, Coimbra District, Portugal Recruiting
• RISE-Health, Center for Translational Health and Medical Biotechnology Research (TBIO), School of Health, Polytechnic of Porto
  Porto, Porto District, Portugal Recruiting

Study contacts

• Study coordinator: Catarina A Mateus, PhD
• Email: cms@ess.ipp.pt
• Phone: +351 913474780

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Noninvasive brain stimulation plus augmented reality vision therapy for anisometropic amblyopia in adults

  This trial tests whether adding HD-tDCS to AR-based dichoptic therapy can improve vision in adults with anisometropic amblyopia.

  Recruiting at 2 sites Polytechnic Institute of Porto · Coimbra, Coimbra District and 1 other locations · NCT07752433

• Psilocybin-assisted therapy to help adults with amblyopia see more clearly

  This study tests whether a single or small doses of psilocybin can boost the effectiveness of amblyopia treatment in adults.

  Recruiting Phase 1/2 Johns Hopkins University · Baltimore, Maryland · NCT07920081

• Gabor-based visual training for adults with amblyopia

  This study tests a computer-based Gabor training program to see if it can improve vision in adults aged 18–39 with amblyopia due to anisometropia or strabismus.

  Recruiting Shanghai Eye Disease Prevention and Treatment Center · Shanghai · NCT07764198

• tDCS for paediatric amblyopia

  This study tests whether non-invasive brain stimulation (tDCS) can improve vision for children aged 4–14 with amblyopia who didn’t get enough help from patching.

  Recruiting Universidad de Murcia · Murcia · NCT07547670

• Gamified visual training with occlusion for kids with anisometropic amblyopia

  This trial tests two kid-friendly digital games plus patching to see if they improve vision and motivation in children aged 4–7 with anisometropic amblyopia compared with patching alone.

  Recruiting Xinhua Hospital, Shanghai Jiao Tong University School of Medicine · Shanghai, Shanghai Municipality · NCT07472231

• Combined fluoxetine and patching to improve and maintain vision in amblyopia using OCTA and VEP

  This project will test whether adding fluoxetine to standard eye patching helps improve and maintain vision in people over 10 with amblyopia.

  Recruiting Minia University · Minya, Minya Governorate · NCT07417046

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.