Enhanced treatment for amblyopia using binocular games

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of new protocols for binocular amblyopia treatment, aiming to achieve better visual acuity recovery in children aged 4-10. It compares two alternative treatment protocols that extend the game treatment period beyond the traditional 4 weeks to an 8-week duration. The study involves an 8-week randomized controlled trial with three arms, assessing the outcomes of these new protocols against the standard 10% contrast-increment game protocol. Children who achieve certain visual acuity benchmarks will receive additional training to promote binocular vision.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* age 4-10 y
* male and female
* strabismic, anisometropic, or combined mechanism amblyopia
* amblyopic eye best-corrected visual acuity 0.3-0.8 logMAR
* fellow eye best-corrected visual acuity ≤0.1 logMAR
* interocular visual acuity difference ≥0.3 logMAR
* wearing glasses (if needed) for 8 weeks or no change visual acuity with glasses at 2 visits

  * 4 weeks apart.
* child's ophthalmologist and family must be willing to forgo patching treatment during the 12-week study period
* parent's informed consent
* child must demonstrate understanding and ability to play binocular games

Exclusion Criteria:

* prematurity ≥8 weeks
* coexisting ocular or systemic disease
* developmental delay
* strabismus \>5pd
* any binocular amblyopia treatment in the past 3 months

Where it's running

• Retina Foundation of the Southwest
  Dallas, Texas, United States Recruiting

Study contacts

• Study coordinator: Reed Jost, MS
• Email: reedjost@retinafoundation.org
• Phone: 2143633911

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Psilocybin-assisted therapy to help adults with amblyopia see more clearly

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• Augmented Reality Binocular Therapy for Adult Amblyopia

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• Gabor-based visual training for adults with amblyopia

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  Recruiting Shanghai Eye Disease Prevention and Treatment Center · Shanghai · NCT07764198

• Noninvasive brain stimulation plus augmented reality vision therapy for anisometropic amblyopia in adults

  This trial tests whether adding HD-tDCS to AR-based dichoptic therapy can improve vision in adults with anisometropic amblyopia.

  Recruiting at 2 sites Polytechnic Institute of Porto · Coimbra, Coimbra District and 1 other locations · NCT07752433

• tDCS for paediatric amblyopia

  This study tests whether non-invasive brain stimulation (tDCS) can improve vision for children aged 4–14 with amblyopia who didn’t get enough help from patching.

  Recruiting Universidad de Murcia · Murcia · NCT07547670

• Gamified visual training with occlusion for kids with anisometropic amblyopia

  This trial tests two kid-friendly digital games plus patching to see if they improve vision and motivation in children aged 4–7 with anisometropic amblyopia compared with patching alone.

  Recruiting Xinhua Hospital, Shanghai Jiao Tong University School of Medicine · Shanghai, Shanghai Municipality · NCT07472231

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.