Combined fluoxetine and patching to improve and maintain vision in amblyopia using OCTA and VEP

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, non-randomized comparative controlled study enrolling 75 eyes into three groups: age-matched normal controls, amblyopic eyes treated with patching alone, and amblyopic eyes treated with patching plus fluoxetine. Participants undergo comprehensive eye exams including BCVA, refraction, IOP, OCTA imaging of the macula, and visual evoked potentials (VEP) at baseline, after three months of therapy, and three months after stopping therapy. The study is conducted at the Department of Ophthalmology, Minia University Hospital, with informed consent and local ethics approval. Outcomes focus on changes in visual acuity and neurovascular retinal measures to see if fluoxetine adds benefit to patching.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with unilateral amblyopia \> 10 years old.

Exclusion Criteria:

* Ocular pathology: media opacity, uveitis, glaucoma, retinal or optic nerve diseases, and history of ocular trauma.

  * Poor fixation.
  * Lack of cooperation.
  * Any psychological disorder.

Where it's running

• Faculty of medicine, Minia university
  Minya, Minya Governorate, Egypt Recruiting

Study contacts

• Study coordinator: Alyaa A Abdelmonaem, phD
• Email: alyaa_medicine@yahoo.com
• Phone: 01097814574

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Psilocybin-assisted therapy to help adults with amblyopia see more clearly

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• Augmented Reality Binocular Therapy for Adult Amblyopia

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• Gabor-based visual training for adults with amblyopia

  This study tests a computer-based Gabor training program to see if it can improve vision in adults aged 18–39 with amblyopia due to anisometropia or strabismus.

  Recruiting Shanghai Eye Disease Prevention and Treatment Center · Shanghai · NCT07764198

• Noninvasive brain stimulation plus augmented reality vision therapy for anisometropic amblyopia in adults

  This trial tests whether adding HD-tDCS to AR-based dichoptic therapy can improve vision in adults with anisometropic amblyopia.

  Recruiting at 2 sites Polytechnic Institute of Porto · Coimbra, Coimbra District and 1 other locations · NCT07752433

• tDCS for paediatric amblyopia

  This study tests whether non-invasive brain stimulation (tDCS) can improve vision for children aged 4–14 with amblyopia who didn’t get enough help from patching.

  Recruiting Universidad de Murcia · Murcia · NCT07547670

• Gamified visual training with occlusion for kids with anisometropic amblyopia

  This trial tests two kid-friendly digital games plus patching to see if they improve vision and motivation in children aged 4–7 with anisometropic amblyopia compared with patching alone.

  Recruiting Xinhua Hospital, Shanghai Jiao Tong University School of Medicine · Shanghai, Shanghai Municipality · NCT07472231

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.