tDCS for paediatric amblyopia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, double-blind trial investigates the safety and effectiveness of transcranial direct current stimulation (tDCS) when added to or compared with standard care in children with strabismic or anisometropic amblyopia that did not respond to patching. Participants will receive several sessions of tDCS, a sham control, and assessments of visual acuity, contrast sensitivity, and stereopsis, with objective biomarkers from EEG and other measures. The study aims to determine if tDCS produces meaningful, lasting improvements and whether it can be a faster or complementary option to occlusion therapy. Outcomes include changes in vision and potential cortical neuroplastic changes, particularly relating to GABAergic activity in the visual cortex. Safety and tolerability will be closely monitored throughout.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Children aged 4-14 years.
* Strabismic amblyopia resistant to patching (PEDIG criteria).
* Anisometropic amblyopia resistant to patching (PEDIG criteria).

Exclusion Criteria:

* Ocular pathology.
* Nystagmus.
* Mental disability.
* Cognitive delay.
* Neurological problems incompatible with treatment.
* Pacemakers.
* Intracranial electrodes.
* Implanted defibrillators.
* Cranial pathologies.
* Cranial lesions.
* Withdrawal will occur upon adverse events, protocol deviation, refusal, or loss to follow-up.

Where it's running

• University of Murcia
  Murcia, Spain Recruiting

Study contacts

• Study coordinator: Dr. Francisco Javier Valiente Soriano, Optics and Optometry
• Email: fjvaliente@um.es
• Phone: +34 670 25 58 48

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Gabor-based visual training for adults with amblyopia

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.