Gabor-based visual training for adults with amblyopia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, interventional study uses Gabor-based perceptual learning powered by RevitalVision software to train visual processing at home. Eligible adults with amblyopia will complete an optical correction period and then undergo repetitive visual tasks near their perception threshold to improve eye-brain coordination. The program runs on a home device, and outcomes will be compared to a control approach to determine any vision gains. The trial is conducted at the Shanghai Eye Disease Prevention and Treatment Center in Shanghai, with primary focus on adults who meet specific anisometropia and strabismus criteria. No collaborators are listed beyond the lead sponsor.

Why it matters

Who can join: the full rules

Inclusion Criteria

1. Written informed consent; age 18-39 years inclusive at randomization.
2. Diagnosis of amblyopia, with amblyopic-eye BCVA of approximately 20-70 ETDRS letters (approximately decimal BCVA 0.05-0.6).
3. Amblyopia caused by anisometropia, strabismus, or both, meeting the following definitions:

   Anisometropic amblyopia: interocular spherical-equivalent difference ≥1.00 D or astigmatic difference ≥1.50 D in any meridian, with no manifest strabismus at distance or near.

   Strabismic amblyopia: strabismus at distance or near, or a history of strabismus surgery, without meeting the anisometropia criterion.

   Combined-mechanism amblyopia: meeting both the strabismus and anisometropia criteria.
4. Completion of standardized optical correction and the 8-12-week stability period; absolute difference between week -4 and week 0 ETDRS scores \<5 letters, with no continuing pretreatment improvement trend.
5. Ability to use the study device for home training and accept electronic adherence monitoring.

Exclusion Criteria

1. Eccentric fixation, clinically significant nystagmus, or inability to complete reliable ETDRS testing.
2. Corneal, lenticular, retinal, macular, optic-nerve, or neurologic disease capable of explaining the visual-acuity reduction.
3. Study-eye spherical equivalent \<-8.00 D, or high refractive error judged by the investigator to compromise test reliability.
4. Recent intraocular surgery or ocular trauma, or extraocular-muscle surgery considered likely to affect outcomes.
5. Diplopia at baseline that interferes with safety evaluation, or an unacceptable training risk as judged by the investigator.
6. Patching, penalization, other visual training, or treatment likely to affect amblyopia outcomes within the prespecified period before randomization.
7. Inability to complete follow-up, understand the tasks, or participation in another clinical study likely to affect outcomes.

Where it's running

• Shanghai Eye Disease Prevention and Treatment Center
  Shanghai, China Recruiting

Study contacts

• Study coordinator: Yan Xu
• Email: drxuyan_2004@163.com
• Phone: 021-62982727-856

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Augmented Reality Binocular Therapy for Adult Amblyopia

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• Noninvasive brain stimulation plus augmented reality vision therapy for anisometropic amblyopia in adults

  This trial tests whether adding HD-tDCS to AR-based dichoptic therapy can improve vision in adults with anisometropic amblyopia.

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• tDCS for paediatric amblyopia

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• Gamified visual training with occlusion for kids with anisometropic amblyopia

  This trial tests two kid-friendly digital games plus patching to see if they improve vision and motivation in children aged 4–7 with anisometropic amblyopia compared with patching alone.

  Recruiting Xinhua Hospital, Shanghai Jiao Tong University School of Medicine · Shanghai, Shanghai Municipality · NCT07472231

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.