Comparing patch-free therapy to traditional patching for amblyopia in children

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the effectiveness of patch-free occlusion therapy compared to standard adhesive patch therapy in young children diagnosed with amblyopia. The study involves a randomized allocation of participants to either treatment group, with baseline assessments of visual acuity and other related metrics. Over a 12-week period, children will undergo their assigned therapy at home, with adherence monitored using a Theramon sensor. Visual outcomes will be measured at multiple intervals to determine which method yields better results.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 3-12 years
* male and female
* strabismic, anisometropic, or combined mechanism amblyopia (visual acuity: 0.3-0.8 logMAR)
* interocular visual acuity difference ≥0.3 logMAR
* wearing glasses (if needed) for a minimum of 8 weeks with no change in visual acuity at 2 visits ≥4 weeks apart
* child's ophthalmologist and family willing to forgo standard patching treatment during the study

Exclusion Criteria:

* Prematurity ≥8 wk
* coexisting ocular or systemic disease
* developmental delay
* myopia \> -3.00D

Where it's running

• Retina Foundation
  Dallas, Texas, United States Recruiting

Study contacts

• Study coordinator: Eileen E Birch, PhD
• Email: ebirch@retinafoundation.org
• Phone: 2143633911

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Psilocybin-assisted therapy to help adults with amblyopia see more clearly

  This study tests whether a single or small doses of psilocybin can boost the effectiveness of amblyopia treatment in adults.

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• Augmented Reality Binocular Therapy for Adult Amblyopia

  This trial tests a home-based augmented reality binocular therapy to see if it improves vision in adults 18–40 with anisometropic amblyopia, compared with placebo training.

  Recruiting at 2 sites Polytechnic Institute of Porto · Coimbra, Coimbra District and 1 other locations · NCT07819552

• Gabor-based visual training for adults with amblyopia

  This study tests a computer-based Gabor training program to see if it can improve vision in adults aged 18–39 with amblyopia due to anisometropia or strabismus.

  Recruiting Shanghai Eye Disease Prevention and Treatment Center · Shanghai · NCT07764198

• Noninvasive brain stimulation plus augmented reality vision therapy for anisometropic amblyopia in adults

  This trial tests whether adding HD-tDCS to AR-based dichoptic therapy can improve vision in adults with anisometropic amblyopia.

  Recruiting at 2 sites Polytechnic Institute of Porto · Coimbra, Coimbra District and 1 other locations · NCT07752433

• tDCS for paediatric amblyopia

  This study tests whether non-invasive brain stimulation (tDCS) can improve vision for children aged 4–14 with amblyopia who didn’t get enough help from patching.

  Recruiting Universidad de Murcia · Murcia · NCT07547670

• Gamified visual training with occlusion for kids with anisometropic amblyopia

  This trial tests two kid-friendly digital games plus patching to see if they improve vision and motivation in children aged 4–7 with anisometropic amblyopia compared with patching alone.

  Recruiting Xinhua Hospital, Shanghai Jiao Tong University School of Medicine · Shanghai, Shanghai Municipality · NCT07472231

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.