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Clinical trial Recruiting at 1 site Interventional

Using advanced cardiac imaging to improve treatment for patients with chest pain

Official title: DYnamic CT Stress Myocardial perfusioN, CT Fractional Flow Reserve and Coronary CT Angiography for Optimized treatMent Strategy In Patients With sTable Chest Pain syndromEs

Run by Copenhagen University Hospital, Rigshospitalet · NCT04709900 · Data updated 2026-11-12

This study is testing if using advanced heart imaging techniques can help people with chest pain get better treatment and feel healthier compared to standard care.

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Quick facts

Study typeInterventional
SexAll
Enrollment2000 (estimated)
SponsorCopenhagen University Hospital, Rigshospitalet
Academic / other
Locations1 site (Copenhagen)
StatusRecruiting
StartedDecember 3, 2021
Main results expectedDecember 2026
Study endsDecember 2031
Registry record updatedNovember 5, 2026
Trial IDNCT04709900 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include patients aged 50 and older with chronic chest pain and risk factors for ischemic heart disease, or those aged 65 and older with chest pain.

Probably not a fit

Patients experiencing persistent chest pain with signs of ongoing acute myocardial infarction may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The DYNAMITE trial aims to evaluate whether a treatment strategy based on combined dynamic CT myocardial stress perfusion, fractional flow reserve CT (FFR-CT), and coronary CT angiography can enhance clinical outcomes for patients experiencing chronic chest pain syndromes. This randomized controlled trial will compare the effectiveness of this imaging-guided approach against conventional management strategies in improving morbidity and mortality. The study will include patients with suspected or confirmed ischemic heart disease and will assess both clinical outcomes and symptom relief.

Why it matters

Potential benefit: If successful, this approach could lead to better management of chest pain and reduced risk of serious cardiac events for patients.

How similar studies have gone: Previous studies have shown promise in using advanced imaging techniques for cardiac evaluation, suggesting potential success for this novel approach.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Chest pain in patients with clinically suspected or confirmed ischemic heart disease
* Clinical indication for non-acute coronary evaluation
* Status of coronary revascularization

  1. With previous coronary revascularization - all patients
  2. Without previous coronary revascularization

     1. Age≥65 years - all patients with chest pain
     2. Age\>50 - \<65 years - typical angina pectoris and at least one cardiovascular risk factor and/or previous myocardial infarction

        * Typical angina requiring all 3 criteria present: a) constrictive discomfort in the front of the chest or in the neck, jaw, shoulder or arm, b) precipitated by physical exertion c) relieved by rest or nitrates within 5 min.
        * Cardiovascular risk factors: hypertension, diabetes, hypercholesterolemia, current smoking, family history of ischemic heart disease, previous stroke, peripheral artery disease

Exclusion Criteria:

* Persistent chest pain and signs of ongoing acute myocardial ischemia requiring acute coronary intervention
* Hospitalization and discharge with the confirmed diagnosis acute coronary syndrome (STEMI or NSTEMI) within the last 6 months
* Severe valvular heart disease as primary diagnosis and/or in potential need of percutaneous or surgical valve treatment
* Known severe heart failure (LVEF less than 35%)
* Language, cultural or mental factors preventing the patient from understanding the informed consent form
* Known atrial fibrillation
* Known renal impairment (estimated Glomerular Filtration Rate below \<30 ml/min)
* Known x-ray contrast allergy
* Known intolerance to adenosine infusion

Where it's running

  • Department of Cardiology and Radiology, Rigshospitalet, The Heart Center, Capital Region of Copenhagen, University of Copenhagen
    Copenhagen, Denmark     Recruiting

Study contacts

  • Principal investigator: Klaus F Kofoed, MD — Department of Cardiology, Rigshospitalet, University of Copenhagen, Denmark
  • Study coordinator: Klaus F Kofoed, MD
  • Email: Klaus.kofoed@regionh.dk
  • Phone: 004535458569

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov ↗ Find more trials like this →
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Coronary Artery Disease 385Acute Myocardial Infarction 46Heart Failure 1020Stroke 1573Cardiovascular Diseases 365Copenhagen University Hospital, Rigshospitalet 160
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.