Assessing heart tissue damage in patients with heart aneurysms after a heart attack
Assessment of Myocardial Fibrosis by 18F-FAPI/PET-CT in Patients With Myocardial Infarction-associated Ventricular Aneurysm
This study is testing how heart tissue damage looks in patients with heart aneurysms after a heart attack using special imaging to see if it helps understand their condition better.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 20 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | RenJi Hospital Academic / other |
| Locations | 1 site (Shanghai) |
| Trial ID | NCT06994221 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate myocardial fibrosis in patients with ventricular aneurysm following an acute myocardial infarction using 18F-FAPI PET/CT imaging. Participants will undergo a PET/CT scan during their hospital stay, along with serial echocardiography and follow-up assessments over one year. The study will analyze the relationship between the imaging results and clinical markers of disease progression, providing insights into the nature of myocardial fibrosis in these patients.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18-75 diagnosed with STEMI or NSTEMI and have a ventricular aneurysm.
Not a fit: Patients under 18, pregnant or breastfeeding women, and those with allergies to radio tracers may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of myocardial fibrosis and improve prognosis for patients with heart aneurysms after a heart attack.
How similar studies have performed: While the use of PET imaging in cardiac conditions is established, this specific approach using 18F-FAPI for myocardial fibrosis assessment is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged 18-75 years old * Diagnosed with STEMI or NSTEMI (ACC/AHA guidelines) * Half male and half female * Undergo CAG and PCI treatment; * Receive either echocardiography or CMR to identify a ventricular aneurysm; * Written informed consent Exclusion Criteria: * Patients under the age of 18 years old; * Patients who are pregnant/breastfeeding; * Patients who has a previous history of allergy to radio tracers.
Where this trial is running
Shanghai
- Renji Hospital — Shanghai, China (Recruiting)
Study contacts
- Study coordinator: ZHIGUO ZOU, MD, PhD
- Email: zouzhiguo@renji.com
- Phone: 13524596108
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.