Treating severe gum disease to reduce inflammation in heart attack patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter randomized clinical trial investigates the effects of periodontal therapy on inflammatory activity in atheromatous plaques among patients hospitalized for an acute myocardial infarction (AMI). Participants aged 30 to 70 with severe periodontitis will be randomly assigned to receive either specialized periodontal treatment or standard dental care. Both groups will undergo FDG-PET scans to evaluate inflammation in carotid atherosclerotic plaques at the beginning and after 12 months. The study aims to determine if improved oral health can positively impact cardiovascular inflammation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients hospitalized for an acute myocardial infarction and included in the Frenchie registry
* Score ≥ 5 on the screening questionnaire for periodontitis
* Six teeth at least (excluding wisdom teeth)
* Consent signature
* Affiliation to a French medical insurance (Sécurité Sociale)

Exclusion Criteria:

* Patients with diseases,other than cardiovascular and diabetes, known to change the periodontal state such as AIDS, rheumatoid arthritis, Chediak-Higashi syndrome, Papillon-Lefèvre
* Systemic antibiotic therapy\> 48 hours in the 3 months prior to inclusion
* Acute heart failure
* Uncontrolled ventricular rhythm disorders
* Impossibility for the patient to attend follow-up visits
* Impossibility to maintain the extended position for 20 minutes
* Immunosuppressive therapy\> 1 month in the 6 months prior to inclusion
* Pregnancy, breastfeeding
* Known hypersensitivity to chlorhexidine, povidone, 18-fluoro-deoxyglucose

Where it's running

• Hôpital Bichat, AP-HP
  Paris, France Recruiting

Study contacts

• Principal investigator: Philippe Gabriel STEG — Assistance Publique - Hôpitaux de Paris
• Study coordinator: Philippe Gabriel STEG
• Email: gabriel.steg@aphp.fr
• Phone: 01 40 25 80 80

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.