Investigating how LRP1 signaling affects heart cells during heart attacks
Official title: Modeling of cell-specific LRP1 signaling in acute myocardial infarction
Funded at University of Virginia · NIH-11167804 · Data updated 2026-11-12
This study is looking at how a special protein in heart cells, called LRP1, works during a heart attack, and it aims to find new ways to help patients recover better by using tiny targeted treatments that could protect the heart and reduce damage.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | August 12, 2024 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $784,046 |
| NIH project number | 5R01HL174999-02 |
| Project ID | NIH-11167804 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have recently experienced an acute myocardial infarction.
✕Less likely to help
Patients who have not had a heart attack or those with chronic heart conditions unrelated to acute myocardial infarction may not benefit from this research.
What this research studies
This research focuses on understanding the role of LRP1, a specific receptor in heart cells, during acute myocardial infarction (AMI). By modeling how LRP1 signaling operates in these cells, the research aims to identify ways to improve treatment outcomes for patients experiencing heart attacks. The approach involves using targeted small peptides that engage LRP1 to potentially reduce heart damage and improve healing after an AMI. The study will analyze both the protective and harmful effects of LRP1 signaling in heart tissue.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce heart damage and improve recovery for patients who have suffered a heart attack.
How similar studies have gone: Previous research has shown promising results with LRP1 agonists in reducing heart damage in animal models, indicating potential for success in human applications.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Saucerman, Jeffrey J. — University of Virginia
- Study coordinator: Saucerman, Jeffrey J.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.