Assessing the benefits of ICD implantation in patients with coronary artery disease after cardiac arrest

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates whether implantable cardioverter defibrillator (ICD) implantation provides benefits to patients with coronary artery disease who have survived cardiac arrest due to ventricular fibrillation or sustained ventricular tachycardia. Participants will undergo complete revascularization before receiving the ICD, and the study will focus on those with a left ventricular ejection fraction (LVEF) above 35%. The aim is to determine the effectiveness of ICDs in improving outcomes for these patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with CAD and cardiac arrest due to VF/VT, where angiogram is performed with complete revascularization (PCI, CABG or hybrid coronary revascularization) before ICD implantation. Unfavorable artery for PCI (i.e., excessive vessel tortuosity or chronic total occlusion) or high-risk invasive treatment is not mandatory in order to achive complete revascularization.
* Age ≥18 years
* LVEF \>35% at the time of discharge. The most recent LVEF assessment on which the current medical treatment will be based at the time of entry into the study will be used as baseline LVEF.

Exclusion Criteria:

* Non-ischemic cause of cardiac arrest (i.e. ion channel diseases, non-ischemic cardiomyopathy)
* Previous CABG within the last 3 months before index hospitalization
* Life expectancy less than 1 year or severe neurologic outcome
* Unable or unwilling to give informed consent
* Pregnancy

Where it's running

• Copenhagen University Hospital, Rigshospitalet
  Copenhagen, Denmark Recruiting

Study contacts

• Principal investigator: Reza Jabbari, MD, PhD — Copenhagen University Hospital, Rigshospitalet
• Study coordinator: Reza Jabbari, MD, PhD
• Email: reza.jabbari.02@regionh.dk
• Phone: +4535455380

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.