Effects of aerobic exercise on heart function in patients with heart disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates how different types of aerobic exercise, specifically long and short high-intensity interval training (HIIT) and moderate-intensity training (MIT), affect endothelial function in patients with ischemic heart disease. It aims to determine which exercise method is most effective in improving flow-mediated dilation (FMD) and other health indicators in patients who have recently undergone treatments for heart conditions. Participants will engage in a structured exercise program over a set period, with evaluations to assess their cardiovascular health and fitness levels.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Men and women aged between 45 and 75 years.
* Diagnosed with acute myocardial infarction, unstable or stable angina.
* Treated with percutaneous coronary intervention, coronary artery bypass grafting, or conservative treatment.
* Event or intervention within 3 to 12 months prior to participation in the study.
* Fluency in speaking and reading Spanish.
* Residing in Elche or surrounding areas and able to attend evaluations and the exercise programme (not planning to be absent for more than one week during the programme).
* Functional Class I-II according to the New York Heart Association (NYHA) classification.
* No physical limitations for exercise.
* Stable optimal medical treatment.
* Physically inactive, defined as 1) not meeting the World Health Organization recommendations for both aerobic and strength exercise, and 2) not participating in a structured exercise programme at least 3 days per week for more than 3 months. Both conditions must be met for inclusion. Note: Casual walking is not considered grounds for exclusion.

Exclusion Criteria:

* Use of walking assistive devices.
* Treatment with chemotherapy for any type of cancer in the past 2 years.
* Hospitalisation in an intensive care unit in the past 6 months for reasons other than the ischaemic event.
* Acute myocardial infarction group IV Killip-Kimball.
* Obesity grade III (≥40.0 kg/m²).
* Medical contraindication for inclusion in an exercise programme.
* Diabetes with uncontrolled blood glucose levels.
* Poorly controlled hypertension: resting blood pressure \> 180/110 mmHg.
* Chest pain with exertion or ST-segment changes suggestive of residual ischemia during ergometry. Residual ischemia.
* Severely reduced functional capacity on initial ergometry (\<5 metabolic equivalent of task).
* Left ventricular ejection fraction less than 50%.
* Severe stenosis of the left main coronary artery (\>50% significant disease).
* Severe aortic stenosis, left ventricular outflow tract obstruction (e.g., obstructive hypertrophic cardiomyopathy) or aortic dissection.
* Severe valvulopathy.
* Acute pulmonary embolism or deep vein thrombosis.
* Severe pulmonary hypertension.
* Acute heart failure.
* Acute endocarditis, myocarditis, or pericarditis.
* Acute or chronic renal insufficiency (estimated glomerular filtration rate \<30 ml/min).
* Pulmonary fibrosis or interstitial disease (severe respiratory insufficiency or confirmed chronic obstructive pulmonary disease).
* Uncontrolled cardiac arrhythmias/hemodynamically unstable.
* Permanent or persistent/paroxysmal atrial fibrillation with episodes in the past 6 months.
* High-grade cardiac block.
* Presence of implantable devices: cardiac resynchronization therapy pacemaker, implantable cardioverter defibrillators, or pacemaker.
* Presence of ischaemic symptoms during the incremental exercise test performed before the intervention.
* Severe autonomic or peripheral neuropathy.
* Use of nitrates in pharmacological treatment.
* Any planned surgical or medical intervention during the study period.
* Plans to participate in or current participation in other studies that may interfere with this study.
* Current pregnancy or intention to become pregnant during the study period.

Where it's running

• Instituto de Investigación Sanitaria y Biomédica de Alicante
  Alicante, Alicante, Spain Recruiting
• Centro de Investigación del deporte
  Elche, Alicante, Spain Recruiting

Study contacts

• Study coordinator: Jose Manuel Sarabia, PhD
• Email: jsarabia@umh.es
• Phone: 965222568

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.