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Clinical trials and research at University of Louisville

• 39Clinical trials
• 303NIH research projects
• 6Countries

Newest trials

All recruiting trials (39)

• Non-invasive spinal cord stimulation to improve blood pressure control after spinal cord injury

  We will test whether non-invasive spinal cord stimulation can help adults with chronic spinal cord injuries at or above T1 who have troublesome low or unstable blood pressure.

  Recruiting University of Louisville · Louisville, Kentucky and 1 other locations · NCT07504055

• Dome-only coiling for severe aneurysmal subarachnoid hemorrhage

  This will test a minimally invasive dome-protection coiling procedure to prevent re-bleeding in adults who have had a severe aneurysmal subarachnoid hemorrhage.

  Recruiting University of Louisville · Louisville, Kentucky · NCT07250958

• Betadine versus sterile water for cleaning the urethra before straight catheter placement

  This study will test whether cleaning the urethra with sterile water or Betadine changes urine bacteria and how much discomfort adults feel when they get an in‑office straight catheter.

  Recruiting at 2 sites Phase 4 University of Louisville · Louisville, Kentucky and 1 other locations · NCT07044726

• No perioperative dexamethasone for brain metastasis surgery

  This trial will try skipping perioperative dexamethasone in adults having surgery for newly diagnosed brain metastases to see if it is safe and reduces lymphopenia.

  Recruiting University of Louisville · Louisville, Kentucky · NCT07044557

• Reactions to Distress (RED) — Louisville, KY

  This study tests whether a brief, culturally-informed mindfulness exercise can reduce threat-focused attention in Black adults who have experienced race-related stress and whether race-related stress increases attention to threat compared with non-race stress.

  Recruiting University of Louisville · Louisville, Kentucky · NCT07016945

• Saline versus balanced crystalloid fluids for moderate-to-severe traumatic brain injury

  This will test whether giving saline or a balanced crystalloid fluid to people with moderate-to-severe traumatic brain injury leads to better recovery.

  Recruiting Phase 3 University of Louisville · Louisville, Kentucky · NCT06953674

• Effects of Osteopathic Manipulative Therapy on Long COVID symptoms

  This study is testing whether Osteopathic Manipulative Therapy can help people with Long COVID feel better by reducing their symptoms over eight weeks.

  Recruiting University of Louisville · Louisville, Kentucky · NCT06883513

• Understanding perinatal spinal cord injury and how targeted therapy may help

  This study tests whether tailored activity-based recovery training plus noninvasive spinal stimulation can improve function in children who had a spinal cord injury at birth or before birth.

  Recruiting University of Louisville · Louisville, Kentucky · NCT06808035

• Non-invasive spinal cord stimulation for improving gait in Parkinson's disease

  This study is testing whether a new non-invasive spinal cord stimulation can help people with Parkinson's disease walk better when their usual medication isn't working.

  Recruiting University of Louisville · Louisville, Kentucky · NCT06804642

• Comparing two methods for pudendal nerve block in pelvic pain treatment

  This study is testing two different ways to give a nerve block to see which one helps women with pelvic pain feel better.

  Recruiting Phase 4 University of Louisville · Louisville, Kentucky · NCT06644261

• Treatment for liver cancer patients after surgery or ablation

  This study is testing if a single injection of a new treatment called IP-001 can help prevent liver cancer from coming back in patients who have just had surgery or ablation.

  Recruiting Phase 2 University of Louisville · Louisville, Kentucky · NCT06526338

• Monitoring blood vessel function and brain blood flow in patients with brain injuries

  This study is testing a new way to monitor blood flow and oxygen levels in the brains of patients with serious brain injuries to help doctors understand their condition better.

  Recruiting University of Louisville · Louisville, Kentucky · NCT06511804

• Carnosine supplementation for improving walking ability in patients with peripheral arterial disease

  This study is testing if taking carnosine for six months can help people with peripheral arterial disease walk better.

  Recruiting Phase 1/2 University of Louisville · Louisville, Kentucky and 2 other locations · NCT06480760

• Helping older adults manage chronic diseases after incarceration

  This study is trying to help older adults who have just been released from prison manage their chronic diseases better by creating a special program just for them.

  Recruiting University of Louisville · Louisville, Kentucky · NCT06276452

• Personalized treatment for eating disorders

  This study is testing a new personalized treatment for adults with eating disorders like anorexia and bulimia to see if it can help them respond better to therapy.

  Recruiting University of Louisville · Louisville, Kentucky · NCT06208605

• Using umbilical cord cells to treat ischemic heart disease

  This study is testing if giving umbilical cord cells to people with heart disease can help improve their heart function.

  Recruiting at 3 sites Phase 2 University of Louisville · Miami, Florida and 2 other locations · NCT06145035

• Using spinal cord stimulation to improve breathing in patients with spinal cord injuries

  This study is testing if combining spinal cord stimulation with breathing exercises can help improve lung function in people with spinal cord injuries.

  Recruiting University of Louisville · Louisville, Kentucky · NCT06019949

• Reducing alcohol use in PrEP users through SBIRT intervention

  This study is testing if a program that helps people cut down on drinking can improve the health of those using PrEP for HIV prevention and help them stick to their medication.

  Recruiting University of Louisville · Louisville, Kentucky · NCT06005298

• Combination therapy for recurrent ovarian cancer using doxorubicin and Ashwagandha

  This study is testing if a combination of a cancer drug and Ashwagandha can help women with recurrent ovarian cancer feel better and respond to treatment.

  Recruiting Phase 1/2 University of Louisville · Louisville, Kentucky · NCT05610735

• Understanding how we perceive distances while moving

  This study is testing how people judge distances while moving around to see how it affects everyday activities like walking and driving.

  Recruiting University of Louisville · Louisville, Kentucky · NCT05419713

• Registry and biorepository for esophageal and gastric conditions

  This study is trying to learn more about how the esophagus and stomach work in people with gastroesophageal reflux disease by using new testing methods and collecting samples to improve diagnosis and treatment.

  Recruiting University of Louisville · Louisville, Kentucky · NCT05180253

• Testing LGG for Alcohol Use Disorder and Liver Injury

  This study is testing if a probiotic called LGG can help people with Alcohol Use Disorder and liver issues drink less and improve their liver health over six months.

  Recruiting Phase 2 University of Louisville · Louisville, Kentucky · NCT05178069

• Improving breathing in spinal cord injury patients using stimulation and training

  This study is testing if combining spinal cord stimulation with breathing exercises can help improve breathing in patients with spinal cord injuries.

  Recruiting University of Louisville · Louisville, Kentucky · NCT05178056

• Palliative radiation combined with pembrolizumab for advanced breast cancer

  This study is testing whether combining a type of radiation therapy with a cancer-fighting drug can help women with advanced breast cancer who haven’t responded to previous treatments.

  Recruiting Phase 2 University of Louisville · Louisville, Kentucky · NCT04990921

• Comparing two devices for difficult airway intubation

  This study is testing if a new device for helping doctors intubate patients with difficult airways works as well as a standard device when used with a video camera.

  Recruiting at 2 sites University of Louisville · Louisville, Kentucky and 1 other locations · NCT04866472

• Using peppermint oil to treat bladder pain syndrome

  This study is testing if peppermint oil can help people with bladder pain syndrome feel better over eight weeks compared to a placebo.

  Recruiting Phase 1/2 University of Louisville · Louisville, Kentucky · NCT04845217

• Investigating the role of heavy metals in pulmonary arterial hypertension

  This study is trying to see if levels of heavy metals in the body affect people with pulmonary arterial hypertension and how their condition changes over a year.

  Recruiting University of Louisville · Louisville, Kentucky · NCT04756076

• Effect of beta-glucan on immune response in advanced melanoma patients

  This study is testing if taking beta-glucan along with Pembrolizumab can boost the immune response in patients with advanced melanoma and help them live longer without the cancer coming back.

  Recruiting University of Louisville · Louisville, Kentucky · NCT04513028

• Using IVIG to treat gastrointestinal autoimmune neuropathy

  This study is testing whether intravenous immunoglobulin (IVIG) can help people with autoimmune gastrointestinal issues feel better when other treatments haven't worked.

  Recruiting University of Louisville · Louisville, Kentucky · NCT04208828

• Mapping autonomic and enteric functions in patients with obesity

  This study looks at how different body functions relate to obesity by comparing patients' stomach emptying times and other health measures to see if there’s a connection.

  Recruiting University of Louisville · Louisville, Kentucky · NCT04013282

• Vagal nerve stimulation for autoimmune and gastrointestinal conditions

  This study is testing if vagal nerve stimulation can improve immune and gut health in patients getting the treatment for epilepsy.

  Recruiting at 2 sites University of Louisville · Louisville, Kentucky and 3 other locations · NCT03953768

• Longitudinal database for patients with gastroparesis symptoms

  This study is tracking patients with gastroparesis symptoms over time to see how their health and quality of life change, regardless of the treatments they receive.

  Recruiting University of Louisville · Louisville, Kentucky · NCT03876288

• Pre-operative immunotherapy for stage III melanoma

  This study is testing a combination of two immunotherapy treatments to see if they can shrink tumors in patients with stage III melanoma before they have surgery.

  Recruiting Phase 2 University of Louisville · Louisville, Kentucky · NCT03842943

• Examining the impact of green spaces on heart health in Louisville

  This study is testing if having more green spaces in Louisville can help improve heart health and reduce disease risk for the people living there.

  Recruiting University of Louisville · Louisville, Kentucky · NCT03670524

• Combining chemotherapy with irreversible electroporation for advanced pancreatic cancer

  This study is testing if combining a special treatment called irreversible electroporation with chemotherapy can help people with advanced pancreatic cancer feel better and manage their disease.

  Recruiting Phase 1 University of Louisville · Louisville, Kentucky · NCT03484299

• Combining immunotherapy with irreversible electroporation for advanced pancreatic cancer

  This study is testing if combining a special cancer treatment called irreversible electroporation with the immunotherapy drug Nivolumab can help people with advanced pancreatic cancer do better than with standard treatments.

  Recruiting Phase 2 University of Louisville · Louisville, Kentucky · NCT03080974

• Registry for pancreatic cancer treatment outcomes using irreversible electroporation

  This study is creating a registry to see how well irreversible electroporation treatment works for people with pancreatic cancer and to track any side effects they might have.

  Recruiting at 16 sites University of Louisville · Birmingham, Alabama and 15 other locations · NCT02674100

• Combining Vemurafenib and Metformin for Melanoma Treatment

  This study is testing if combining the cancer drug Vemurafenib with Metformin can help people with advanced melanoma feel better and live longer.

  Recruiting Phase 1/2 University of Louisville · Louisville, Kentucky · NCT01638676

• Effect of beta-glucan on immune response in lung cancer patients

  This study tests if a dietary supplement called beta-glucan can help boost the immune system in people with non-small cell lung cancer.

  Recruiting University of Louisville · Louisville, Kentucky · NCT00682032

NIH-funded research (newest 40 of 303)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Gastric rhythm map to understand stomach problems using a new noninvasive tool

  A new noninvasive body surface mapping method is being tested to see if abnormal stomach electrical rhythms explain chronic stomach problems like functional dyspepsia and persistent nausea.

  NIH research University of Louisville · Louisville, United States · NIH-11611507

• Novel antivirals for alphavirus arthritis

  A research team is refining a promising antiviral compound to treat alphavirus infections that cause arthritis, with a focus on Chikungunya and related viruses.

  NIH research University of Louisville · Louisville, United States · NIH-11609180

• Linking heavy metal exposure to a tougher breast cancer type (TNBC)

  Aimed at understanding how heavy metals like cadmium might trigger a dangerous breast cancer type (TNBC) in people, especially those with BRCA1 risk, to identify possible future treatment strategies.

  NIH research University of Louisville · Louisville, United States · NIH-11567535

• Cardiac safety of flavored e-cigarette aerosols in adults

  A pharmacist or clinician would test how inhaling flavored e-cigarette aerosols affects heart rhythm in adults to see if flavors raise the risk of heart problems.

  NIH research University of Louisville · Louisville, United States · NIH-11541950

• Biomedical Research Facilities to Expand Precision Medicine in Kentucky

  A large NIH grant aims to renovate and expand a shared precision medicine center in Kentucky to speed up research that could improve health for people in Appalachia and surrounding areas.

  NIH research University of Louisville · Louisville, United States · NIH-11523167

• Rac-enhanced CAR-Macrophages against TNBC

  A new cell therapy approach uses engineered macrophages with a CAR and Rac2 activation to target and kill triple-negative breast cancer cells expressing CSPG4.

  NIH research University of Louisville · Louisville, United States · NIH-11520503

• How vitamin B12 helps the gum-disease bacterium survive

  Learning how vitamin B12 helps the bacteria that cause gum disease survive and become more harmful for people with periodontitis.

  NIH research University of Louisville · Louisville, United States · NIH-11506468

• Antiviral drug development against Zika virus focusing on NS4B

  Researchers are developing a new oral medicine to fight Zika virus by targeting a key viral protein, aiming to help people at risk of severe Zika outcomes.

  NIH research University of Louisville · Louisville, United States · NIH-11503479

• How arsenic exposure causes cancer

  Researchers are looking at how low-level arsenic exposure changes small RNAs and gene splicing in skin cells to explain why some people develop arsenic-related skin cancer.

  NIH research University of Louisville · Louisville, United States · NIH-11467959

• Effects of activity-based recovery training on bladder and bowel function after spinal cord injury

  A study from University of Louisville explores noninvasive therapies to improve bladder and bowel function in people with spinal cord injury, including children and adults.

  NIH research University of Louisville · Louisville, United States · NIH-11450679

• Ventral pallidum brain stimulation for epilepsy

  A brain stimulation therapy in people with epilepsy whose seizures aren’t controlled by medicines or surgery is being studied to see if it can help achieve seizure freedom.

  NIH research University of Louisville · Louisville, United States · NIH-11450530

• How age and sex change tiny blood vessels after a spinal cord injury

  This research looks at how aging and biological sex change blood flow in the injured cervical spinal cord to help people with spinal cord injuries, especially older adults.

  NIH research University of Louisville · Louisville, United States · NIH-11446856

• How blood flow affects gray matter loss after neck spinal cord injury

  This work looks at whether changing blood flow after a cervical (neck) spinal cord injury might protect gray matter and help recovery for people with these injuries.

  NIH research University of Louisville · Louisville, United States · NIH-11446855

• Understanding and improving support for male dementia caregivers

  This project focuses on what helps or hinders men who care for people with dementia, with new ideas to reach and support them better.

  NIH research University of Louisville · Louisville, United States · NIH-11444413

• Novel negative pressure lung perfusion device for donor lung rehabilitation

  A new automated system uses gentle negative pressure to run donor lungs outside the body, while delivering targeted antibiotics to improve lung quality for transplant.

  NIH research University of Louisville · Louisville, United States · NIH-11440841

• Metabolite-based approach to strengthen the premature gut

  A doctor-scientist team will test a metabolite and a synthetic version to help the immature intestines of very premature babies develop better defenses against NEC.

  NIH research University of Louisville · Louisville, United States · NIH-11437498

• New antiviral candidates to treat arthritogenic alphaviruses like chikungunya

  A research team is refining a promising chemical scaffold to create antiviral drugs that could treat infections from alphaviruses such as chikungunya, aiming to help people who get sick from these viruses.

  NIH research University of Louisville · Louisville, United States · NIH-11423711

• Chromosome Instability and Metal-Linked Lung Cancer

  This grant explores how metal exposure can start or worsen lung cancer by causing chromosome instability, with a focus on cells from the human lung.

  NIH research University of Louisville · Louisville, United States · NIH-11417485

• Gastric electrical stimulation for stomach pain in gastroparesis

  A new approach tests how adjusting a stomach-stimulating implant may reduce pain for people with gastroparesis.

  NIH research University of Louisville · Louisville, United States · NIH-11416260

• Emergency neutrophil production and heart healing after a heart attack

  A study explores how the body’s emergency production of white blood cells after a heart attack affects heart healing and scar formation.

  NIH research University of Louisville · Louisville, United States · NIH-11415764

• Anxiety and body-sense as a warning for eating disorders in kids

  This project looks at whether anxiety and how kids sense their internal body signals can signal the kind of eating problems that lead to eating disorders in children and teens.

  NIH research University of Louisville · Louisville, United States · NIH-11412713

• Double-negative T cells and breast cancer immunity

  Aims to understand how a special type of immune cells called double-negative T cells could help fight breast cancer, especially tough cases like triple-negative breast cancer.

  NIH research University of Louisville · Louisville, United States · NIH-11408721

• Integrated therapies for alcohol use and ALD: a patient-centered network

  A nationwide network at the University of Louisville will test combined medical and behavioral care to help people with alcohol-associated liver disease, including severe alcohol-related hepatitis.

  NIH research University of Louisville · Louisville, United States · NIH-11408543

• How AHR and NLRP6 affect the gut lining in colitis

  This work explores whether a gut microbe–derived compound called Urolithin A can strengthen the intestinal barrier and help people with inflammatory bowel disease like Crohn’s and ulcerative colitis.

  NIH research University of Louisville · Louisville, United States · NIH-11401873

• Motivation-based teen vaping profile to guide quitting help

  Aims to understand why adolescents vape and use that knowledge to tailor stopping tools that fit teens.

  NIH research University of Louisville · Louisville, United States · NIH-11399916

• Role of tissue stiffness in brain tumor immunity

  A study in glioblastoma patients and models aims to understand how the stiffness of the tumor environment affects immune cells and tumor growth.

  NIH research University of Louisville · Louisville, United States · NIH-11399795

• DP1 receptor signaling and aging immune function in lung cancer spread

  A doctor-science team is studying how aging changes immune responses in the lungs to better control metastatic cancer and viral infections, using a specific pathway involving DP1 and PLA2G2D.

  NIH research University of Louisville · Louisville, United States · NIH-11399790

• Zika virus–based approach to boost immune attack on glioblastoma

  Aims to use a Zika virus–driven approach to train the body’s immune system to attack glioblastoma tumors by activating myeloid cells and CD8 T cells.

  NIH research University of Louisville · Louisville, United States · NIH-11399786

• Center for Cancer Immunology and Immunotherapy: Functional Immunomics Core for Immune Profiling in Cancer

  A patient-facing center is building advanced immune profiling capabilities to study how immune cells interact with tumors using mouse models, tissue samples, and new imaging technologies.

  NIH research University of Louisville · Louisville, United States · NIH-11399782

• Center for Cancer Immunology and Immunotherapy Admin Core (CCII)

  A center at the University of Louisville is coordinating research efforts to understand cancer immunology and develop new immunotherapies, with a focus on supporting investigators and pilot projects.

  NIH research University of Louisville · Louisville, United States · NIH-11399779

• Center for Cancer Immunology and Immunotherapy at University of Louisville

  A cancer-immunology center at the University of Louisville is renewing support to advance tumor immunology research and train the next generation of scientists to use the immune system to fight cancer.

  NIH research University of Louisville · Louisville, United States · NIH-11399778

• Alcohol, Gut Health, and PrEP: How a brief intervention might help HIV prevention care

  A program to help people using PrEP reduce risky drinking and improve gut health so they can stay on PrEP.

  NIH research University of Louisville · Louisville, United States · NIH-11396995

• KE-PIRC: Kentucky pediatric health center improving kids’ health through research collaboration

  A Kentucky pediatric training and research program partners with local clinics to strengthen clinical trials and child health outcomes.

  NIH research University of Louisville · Louisville, United States · NIH-11396215

• How environmental chemicals affect teen sleep and stress

  Researchers are studying whether everyday chemical exposures in early life affect sleep quality and stress-related health during adolescence.

  NIH research University of Louisville · Louisville, United States · NIH-11394814

• Controlled PTEN reduction to help spinal cord nerves regrow after injury

  A scientist team is testing a way to safely reduce a growth-inhibiting protein (PTEN) in adults with spinal cord injury to help the nerves in the spinal cord regrow and restore movement.

  NIH research University of Louisville · Louisville, United States · NIH-11394619

• Turning scar-forming support cells into neurons to repair spinal cord injuries

  This project uses a cell-reprogramming approach to make support cells into new nerve cells to help people with spinal cord injuries regain function.

  NIH research University of Louisville · Louisville, United States · NIH-11393167

• Gastroparesis: understanding causes and improving treatments for this stomach-emptying disorder

  A national research effort at University of Louisville is studying why gastroparesis happens and how to treat it, with patients experiencing symptoms like nausea, vomiting, and abdominal pain in mind.

  NIH research University of Louisville · Louisville, United States · NIH-11386523

• Community Engagement and Outreach Core (CEO) for Translational Health in Kentucky

  A program to strengthen community partnerships and researcher collaboration so people in Kentucky can participate in and benefit from clinical and translational research on chronic disease.

  NIH research University of Louisville · Louisville, United States · NIH-11382439

• Health Resources Core supports clinical and translational research at UofL

  A Health Resources core at the University of Louisville helps doctors and researchers work together to turn ideas into real health improvements for patients.

  NIH research University of Louisville · Louisville, United States · NIH-11382438

• Data-driven support for cancer research design and compliance

  A cancer center grant to help researchers design studies, manage data, and access patient records to support clinical trials and translational work.

  NIH research University of Louisville · Louisville, United States · NIH-11382434

Quick answers

How many clinical trials run by University of Louisville are recruiting right now?

39, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (39 trials), Canada (1 trial), Japan (1 trial), Mexico (1 trial), Taiwan (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 6, Phase 1/2: 4, Phase 4: 2, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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