Integrated therapies for alcohol use and ALD: a patient-centered network
Official title: Integrated therapies for alcohol use and ALD (ITAALD) Network -UofL Clinical Center
Funded at University of Louisville · NIH-11408543 · Data updated 2026-11-12
A nationwide network at the University of Louisville will test combined medical and behavioral care to help people with alcohol-associated liver disease, including severe alcohol-related hepatitis.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Louisville NIH-funded |
| Lab location | 1 site (Louisville, United States) |
| Project start | August 1, 2018 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $344,300 |
| NIH project number | 5U01AA026980-08 |
| Project ID | NIH-11408543 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with alcohol-associated liver disease, including severe alcohol-related hepatitis, who may benefit from integrated medical and behavioral treatment.
✕Less likely to help
Patients not able to participate in a combined medical-behavioral program or who do not have alcohol-use disorder may see limited benefit.
What this research studies
This project brings together liver disease and addiction care teams to create an integrated treatment approach for ALD and alcohol use disorder. It aims to test how combining medical treatments with counseling and motivational support can improve outcomes for patients with ALD, especially those with severe alcohol-related hepatitis. The study will explore potential therapies like IL-22 and acamprosate, alongside evidence-based behavioral strategies. By addressing stigma and coordinating care, the program seeks to help patients stay in treatment and reduce liver-related complications. Participation would involve medical assessments, discussion of alcohol use, and adherence to a treatment plan guided by the integrated team.
Why it matters
Potential benefit: If successful, patients could experience better liver health, fewer complications, and improved quality of life through coordinated medical and behavioral care.
How similar studies have gone: Previous interim results in related areas suggest potential benefits of integrated care, but this project seeks to confirm and extend those findings in ALD patients.
Where this research is happening
-
University of Louisville
Louisville, United States Active
Researchers
- Principal investigator: Mcclain, Craig J. — University of Louisville
- Study coordinator: Mcclain, Craig J.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.