Reactions to Distress (RED) — Louisville, KY
Official title: Reactions to Experiencing Distress (RED) Study
Run by University of Louisville · NCT07016945 · Data updated 2026-11-12
This study tests whether a brief, culturally-informed mindfulness exercise can reduce threat-focused attention in Black adults who have experienced race-related stress and whether race-related stress increases attention to threat compared with non-race stress.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 270 (estimated) |
| Sponsor | University of Louisville Academic / other |
| Locations | 1 site (Louisville, Kentucky) |
| Status | Recruiting |
| Started | July 25, 2024 |
| Main results expected | April 30, 2027 |
| Study ends | April 30, 2027 |
| Registry record updated | June 12, 2025 |
| Trial ID | NCT07016945 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 or older who identify as Black or African American, have personally experienced or witnessed racism or racial microaggressions, and can attend a 1.5-hour visit at the University of Louisville in the study window.
✕Probably not a fit
People who do not identify as Black/African American, who have not experienced race-related stress, or who cannot travel to the Louisville lab are unlikely to benefit from or be eligible for this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Researchers will recruit 200 Black adults who report having experienced or witnessed race-related stress for a single 1.5-hour laboratory visit at the University of Louisville. Participants will experience either race-related or non-race-related stress inductions while their eye movements are tracked to measure attention to threatening stimuli. After the stress induction, participants will be randomly assigned to a brief culturally-informed mindfulness audio or a neutral audio control, and attention bias to threat will be measured again. The study will also measure racial identity to see if it changes how stress affects attention or how well the mindfulness exercise works.
Why it matters
Potential benefit: If successful, the study could identify a short, culturally-tailored mindfulness practice that reduces threat-focused attention after race-related stress and might help lower related symptoms.
How similar studies have gone: Previous lab studies show mindfulness and attention-bias methods can shift attention, but applying a brief culturally-informed mindfulness exercise specifically to race-related attention bias is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Eligibility for this study will include a positive response to the following questions: 1) Do you identify as Black or African American? 2) Have you ever in your lifetime personally experienced or witnessed another person experience any acts of racism or racial microaggressions? 3) Are you willing to complete a 1.5-hour study at the University of Louisville in the next 2 weeks? 4) Are you 18 or older? Exclusion Criteria: * None
Where it's running
-
Davidson Hall
Louisville, Kentucky, United States Recruiting
Study contacts
- Study coordinator: Yara Mekawi, PhD
- Email: yara.mekawi@louisville.edu
- Phone: 16308636375
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.