Emergency neutrophil production and heart healing after a heart attack
Official title: Emergency Granulopoiesis in Ventricular Remodeling
Funded at University of Louisville · NIH-11415764 · Data updated 2026-11-12
A study explores how the body’s emergency production of white blood cells after a heart attack affects heart healing and scar formation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Louisville NIH-funded |
| Lab location | 1 site (Louisville, United States) |
| Project start | September 15, 2025 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $713,958 |
| NIH project number | 5R01HL175510-02 |
| Project ID | NIH-11415764 on NIH RePORTER |
Who could benefit from this research
✓Could help
People who have experienced a heart attack or are at risk of cardiovascular disease may benefit from this research as it may inform future therapies.
✕Less likely to help
Individuals without cardiovascular disease or not at risk for MI are unlikely to benefit directly.
What this research studies
After a heart attack, the body launches an immune response that brings in many neutrophils to help with healing. This project asks how how quickly and how many neutrophils are produced during emergency granulopoiesis and how that impacts heart tissue repair and scar formation. By studying mouse models and human data, researchers aim to link neutrophil dynamics to heart function after injury and identify potential ways to balance inflammation and healing. The goal is to uncover factors that could improve outcomes for people recovering from a heart attack.
Why it matters
Potential benefit: If successful, the work could lead to new strategies to optimize immune responses after a heart attack and improve heart repair.
How similar studies have gone: Previous studies show that neutrophil levels relate to heart injury severity, but how emergency neutrophil production affects healing is not well understood.
Where this research is happening
-
University of Louisville
Louisville, United States Active
Researchers
- Principal investigator: Wysoczynski, Marcin — University of Louisville
- Study coordinator: Wysoczynski, Marcin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.