Mapping autonomic and enteric functions in patients with obesity
Adrenergic Cholinergic Enteric Measures/Mapping
This study looks at how different body functions relate to obesity by comparing patients' stomach emptying times and other health measures to see if there’s a connection.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 500 (estimated) |
| Ages | 10 Years to 80 Years |
| Sex | All |
| Sponsor | University of Louisville Academic / other |
| Locations | 1 site (Louisville, Kentucky) |
| Trial ID | NCT04013282 on ClinicalTrials.gov |
What this trial studies
This observational study examines patients who underwent autonomic and enteric profiling at the University of Louisville between 2012 and 2019. It records the results of these physiologic measures and compares them to standardized gastric emptying values as the primary outcome. Additionally, the study evaluates metabolic measures such as weight and BMI, as well as gastrointestinal symptoms reported by patients. The goal is to better understand the relationship between these measures and obesity.
Who should consider this trial
Good fit: Ideal candidates for this study are patients exhibiting symptoms suggestive of autonomic and/or enteric disorders.
Not a fit: Patients with anatomic obstructions of the GI tract, pregnancy, or psychiatric disorders that hinder assessment may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into the physiological mechanisms underlying obesity, potentially leading to improved treatment strategies.
How similar studies have performed: While this approach is observational and builds on existing profiling techniques, similar studies have shown promise in understanding the autonomic and enteric contributions to obesity.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with the symptoms suggestive of autonomic and/or enteric disorders. Exclusion Criteria: * Anatomic obstruction of the GI tract * Pregnancy * Inability of patient or guardian to sign informed consent, if needed * Psychiatric disorders precluding assessment and treatment of the patient's GI condition.
Where this trial is running
Louisville, Kentucky
- University of Louisville — Louisville, Kentucky, United States (Recruiting)
Study contacts
- Principal investigator: Thomas Abell — University of Louisville
- Study coordinator: Thomas L Abell
- Email: thomas.abell@louisville.edu
- Phone: (502)852-6991
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.