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Clinical trials and research at UNC Lineberger Comprehensive Cancer Center
As of November 12, 2026, Find a Trial lists 73 clinical trials run by UNC Lineberger Comprehensive Cancer Center that are recruiting, at sites in 4 countries (most in United States (71), South Africa (1), Malawi (1)). 1 was first registered in the last 30 days. By phase: Phase 2 (15), Phase 1 (11), Phase 1/2 (3), Phase 3 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 73Clinical trials
- 1New in 30 days
- 4Countries
Newest trials
All recruiting trials (73)
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Personalized navigation to support rural and Black women with endometrial cancer
This pilot tests a tailored patient-navigation program to help rural and Black patients with endometrial cancer access care and services.
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One year vs two years of maintenance immunotherapy for endometrial cancer
This trial tests whether keeping pembrolizumab or dostarlimab for one year works as well as two years for people with advanced, recurrent, or metastatic endometrial cancer who completed initial chemo and anti-PD1 therapy.
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Keep Social: A 7-Week Program for Young Adults with Cancer
This trial tests whether a social connectedness intervention delivered via a simulated social media platform can improve social and emotional well-being for young adults in the US who were diagnosed with cancer as adolescents or young adults.
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NeoAdjuvant PD-1–Based Therapy in Resectable Advanced Melanoma (NASA)
In people with resectable stage IIIB–IV melanoma, this study tests whether two infusions of pembrolizumab or a combination of ipilimumab plus nivolumab given before surgery can keep people alive at 2 years without needing additional adjuvant therapy.
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Heart-friendly medicines to protect chest-area cancer patients from radiation damage
This Phase 2 trial tests whether taking atorvastatin and lisinopril can reduce heart damage in adults with chest-area cancers who receive radiation therapy.
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Strength Training for Kids with Acute Lymphoblastic Leukemia and Lymphoblastic L lymphoma
Researchers are testing a structured strength-training program for children and teens recently diagnosed with ALL or lymphoblastic lymphoma to see if it helps with weight gain and physical function during treatment.
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Does the time of day for PD-1/PD-L1 therapy affect response in NSCLC and HNSCC
In people with advanced NSCLC or resectable head and neck cancer, this study tests whether receiving PD-1/PD-L1 therapy in the morning versus the afternoon changes treatment outcomes.
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Kyphoplasty combined with radiofrequency ablation and radiation for painful thoracic and lumbar spine tumors
This treatment plan tries to reduce moderate-to-severe back pain in adults whose cancer has spread to the thoracic or lumbar spine by combining kyphoplasty, radiofrequency ablation (OsteoCool), and external beam radiation.
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AI-assisted pre-treatment peer review to boost prostate cancer radiation safety
This study tests AI and ML tools that help a multidisciplinary team review prostate cancer radiation plans before treatment to catch errors and improve patient safety.
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Comparing clinic-only versus clinic plus community outreach to offer HPV self-collection for cervical screening in women with HIV
This project will test whether adding community health worker outreach to clinic services helps more women living with HIV complete HPV self-collection for cervical screening.
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Nutrition awareness for women after non-metastatic breast cancer
This online program tests whether an educational brochure and short surveys can help women who have finished treatment for non-metastatic breast cancer recognize unhealthy processed foods and be willing to change their diet.
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Adaptive biomarker-driven therapies for metastatic breast cancer
This trial tests whether matching targeted drug combinations to tumor biomarkers helps people with ER+/HER2- or triple-negative metastatic breast cancer who are starting second-line treatment.
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Increasing exercise for people with metastatic breast cancer using the Get Real and Heel program
This project will try offering the Get Real and Heel (GRH) exercise program to people with metastatic breast cancer at UNC to see if it increases physical activity and improves symptoms and quality of life.
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Hyaluronic acid gel spacer to protect nearby organs during cervical cancer radiation
This pilot tests a hyaluronic acid gel spacer (Barrigel) to see if it helps people with cervical cancer receiving chemoradiotherapy and brachytherapy by creating space between the tumor and nearby organs.
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Using MRI to spare parotid salivary ducts to reduce dry mouth
This study tests whether using MRI to identify and protect parotid salivary ducts during radiation can reduce long-term dry mouth for people receiving definitive radiotherapy for oropharyngeal cancer.
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Preoperative chemotherapy with pembrolizumab and a low or high radiation boost for node-positive triple-negative breast cancer
This study tests whether giving a low or high radiation boost together with preoperative chemotherapy and pembrolizumab can better activate the immune system in people with node‑positive triple‑negative breast cancer.
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Contrast-Enhanced Super-Resolution (CESR) Ultrasound for Imaging Breast, Liver, and Kidney Lesions
The team will try a new contrast-enhanced super-resolution ultrasound (CESR) to see if it images known lesions in the breast, liver, or kidney more clearly in adults scheduled for biopsy and in healthy volunteers.
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Short videos about genetic testing for ovarian and endometrial cancer patients
This pilot will see if watching short English or Spanish videos helps patients with ovarian or endometrial cancer get genetic testing and referrals.
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ctDNA surveillance with Dato-DXd for people with high-risk early triple-negative breast cancer and residual disease
This study will test whether regular blood-based ctDNA monitoring can find tiny relapses in adults with stage II/III triple-negative breast cancer who have residual disease after neoadjuvant therapy and whether early treatment with Dato-DXd when ctDNA becomes positive can reduce recurrence.
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Tirzepatide for obesity-related endometrial cancer
This study will test whether four weeks of tirzepatide before surgery reduces tumor cell growth in obese women with endometrial cancer.
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Finding tiny amounts of tumor DNA in the blood after surgery for early HR+/HER2- breast cancer with 1–3 positive lymph nodes
This project tests whether a blood test that finds tiny bits of tumor DNA after surgery can identify people with early HR+/HER2- breast cancer and 1–3 positive lymph nodes who are more likely to have the cancer come back, including a dedicated group of African American women.
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Pharmacist-led program to help patients take oral cancer medicines as prescribed
This program will test whether pharmacist counseling and risk-based monitoring helps adults with solid tumors or blood cancers who have been on oral cancer medicines for at least six months take their medication more consistently.
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Visual decision tools to support urologists treating prostate and kidney cancer
This project will test whether giving urologists visual decision-support tools changes how they talk with patients newly diagnosed with localized prostate or kidney cancer.
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Combining XL092 and cemiplimab for BRAF V600E–wildtype anaplastic thyroid cancer
This trial will test whether giving XL092 plus cemiplimab before surgery is safe and doable for adults with BRAF V600E–wildtype anaplastic thyroid cancer.
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Radiation therapy for early-stage breast cancer using a shorter treatment schedule
This study is testing a shorter radiation treatment schedule for women 50 and older with early-stage breast cancer to see if it is safe and effective while reducing the number of visits needed.
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Precision oncology navigation with expert genomic review to guide therapy and survival
This tests whether a centralized precision oncology navigator and expert review of NGS results increase the use of genome-informed therapies for people with stage IV breast, lung, colorectal, or bladder cancer.
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Using ultrasound to evaluate breast cancer biomarkers
This study is testing whether special ultrasound techniques can help doctors understand how breast tumors behave and respond to chemotherapy in women with either benign or malignant tumors.
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Personalized exercise and nutrition program to reduce cancer-related fatigue
This program will try a personalized exercise and diet plan to reduce fatigue for adults with indolent lymphomas (including CLL/SLL and follicular lymphoma).
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Promoting resilience in Black women with metastatic breast cancer
This study is testing a new program to see if it can help Black women with metastatic breast cancer feel stronger and improve their quality of life.
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Personalized mobile weight-management program for adolescent and young adult cancer survivors
This trial will test whether a personalized mobile health program helps cancer survivors ages 18–39 with overweight or obesity lose more weight over six months than a self-guided digital program.
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Decision-making support for Spanish-speaking Latina breast cancer survivors
This study is trying to help Spanish-speaking Latina breast cancer survivors make better decisions about breast reconstruction after surgery by gathering their input to improve a decision-making tool.
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Examining organ aging in breast cancer patients undergoing chemotherapy
This study is trying to see how chemotherapy affects the aging of organs in women with early-stage breast cancer to help identify those who might face more risks during treatment.
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Memantine plus structured exercise to protect thinking and memory during breast cancer chemotherapy
This will test whether memantine combined with a supervised exercise program, memantine alone, or a placebo can prevent or reduce thinking and memory problems in people receiving chemotherapy for stage I–III breast cancer.
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Pre-treatment rehabilitation program for cancer patients
This study is testing whether a special exercise and support program before cancer treatment can help high-risk patients feel better and have improved results during their care.
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Evaluating central oncology navigation and a new oncology research navigator for cancer care
This study is testing if a new support system for cancer patients can help improve their care experience, focusing on those newly diagnosed with certain types of cancer.
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Treatment for advanced basal-like pancreatic cancer using a combination of drugs
This study is testing a new combination of drugs to see if it can help people with advanced basal-like pancreatic cancer feel better when standard treatments aren't working.
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Treatment using CAR-T cells targeting B7-H3 for triple-negative breast cancer
This study is testing a new CAR-T cell treatment aimed at a specific target for people with hard-to-treat triple-negative breast cancer to see if it is safe and how much can be given.
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Registry for patients with metastatic cancer receiving radiation therapy
This study collects information from patients with metastatic cancer who are getting radiation therapy to see how well it works and improve future treatments.
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Using modified T cells to treat recurrent ovarian cancer
This study is testing a new treatment using modified immune cells to see if it can help people with recurrent ovarian cancer that hasn't responded to standard treatments.
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Evaluating a decision support tool for patients with blood cancers
This study tests a new tool called PRIME to see if it helps older adults with blood cancers make treatment choices that better match their personal preferences compared to regular care.
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Mobile app to increase Black participation in pancreatic cancer clinical trials
This study is testing a new mobile app designed to help Black individuals with pancreatic cancer get more involved in clinical trials and improve their healthcare experience.
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Using CAR-T cells to target B7-H3 in pancreatic cancer
This study is testing a new treatment using specially modified immune cells to see if they can safely help people with pancreatic cancer that has come back after other treatments.
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Using modified T cells to treat relapsed head and neck cancer
This study is testing a new treatment using modified immune cells to see if it can help people with relapsed head and neck cancer feel better and improve their outcomes.
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New cellular therapy for Hodgkin Lymphoma
This study is testing a new type of cell therapy for people with relapsed or hard-to-treat Hodgkin Lymphoma to see if it is safe and effective.
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Improving thoracic surgical care with remote electronic symptom monitoring
We will try remote electronic symptom monitoring (ePROs) for adults having major thoracic surgery to see if it helps catch complications earlier and reduce serious problems.
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GRID therapy for treating extremity soft tissue sarcoma
This study is testing a new type of radiation therapy called GRID to see if it can safely help people with high-risk soft tissue sarcoma before they have surgery.
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Using brain tumor tissue to predict drug response
This study is trying to see if testing tumor tissue from patients with brain tumors can help find the best treatments for both kids and adults.
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Monitoring disease outcomes and side effects in patients with gastrointestinal cancers and sarcomas
This study is trying to see how standard treatments for gastrointestinal cancers and sarcomas affect patients' health and side effects over time.
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Survey on satisfaction of young adults receiving cancer treatment in different infusion spaces
This study is trying to see how satisfied young adults aged 18-39 are with their cancer treatment experiences in different infusion spaces at a hospital.
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Registry for pleural fluid samples from lung cancer and infection patients
This study is collecting fluid samples from patients with lung cancer or lung infections to see if they can help create better tests and treatments for these conditions.
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Combining Trilaciclib with Lurbinectedin for Small-cell Lung Cancer
This study is testing if adding Trilaciclib can help reduce side effects from Lurbinectedin in patients with advanced small-cell lung cancer who have already tried other treatments.
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Combining ONC201 and Atezolizumab for treating obesity-related endometrial cancer
This study is testing a new treatment for advanced or recurrent endometrial cancer in obese women by combining two drugs, ONC201 and atezolizumab, to see if it helps manage their cancer better.
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Comparing two treatments for low-risk elderly breast cancer patients after surgery
This study is testing whether a type of radiation treatment after surgery can help older women with low-risk breast cancer feel better compared to taking hormone therapy alone.
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Evaluating a prognostic tool for metastatic breast cancer care
This study is trying to see if a new tool that helps doctors predict outcomes for patients with metastatic breast cancer is easy to use and helpful for improving care.
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Urine HPV testing for cervical cancer screening in HIV-infected women in South Africa
This study tests whether using urine samples to check for HPV can help screen for cervical cancer in women living with HIV in South Africa.
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Using CAR-T cells to target B7-H3 in recurrent glioblastoma
This study is testing a new CAR-T cell therapy that targets a specific protein in patients with recurrent glioblastoma to see if it's safe and how much can be given.
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Using lower doses of isatuximab, lenalidomide, and dexamethasone for older patients with newly diagnosed multiple myeloma
This study is testing if using lower doses of isatuximab, lenalidomide, and dexamethasone can safely help older patients with newly diagnosed multiple myeloma feel better while reducing side effects.
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Registry for childhood and young adult cancer patients
This study is creating a registry for young cancer patients to track their health and well-being over time and help improve future care.
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Using blood and urine tests to detect cervical cancer
This study is testing if blood and urine tests can help find and track cervical cancer in patients more easily than current methods.
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Effects of SCFA supplements on GI toxicity in cancer patients receiving radiation therapy
This study is testing if taking short chain fatty acid supplements can help reduce stomach and gut problems in cancer patients getting radiation therapy.
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Observing HPV DNA and genetic markers in oropharyngeal cancer
This study is testing if checking for certain gene changes and HPV DNA in the blood can help predict if oropharyngeal cancer will come back in newly diagnosed patients.
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Treatment using modified T cells for certain types of lymphoma
This study is testing a new treatment using modified immune cells to see if it can help people with certain types of lymphoma that haven't responded to other therapies.
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Blood test for cancer DNA in head and neck cancer patients
This study is testing if a blood test that looks for cancer DNA can help doctors understand how head and neck cancer behaves before and after surgery, and see if it can predict if the cancer will come back.
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Treatment for relapsed or refractory CD30+ T cell lymphoma using modified T cells
This study is testing a new treatment using modified T cells to see if it can help people with relapsed or hard-to-treat CD30+ T cell lymphoma.
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Understanding brain changes after radiation treatment for brain metastases
This study is testing how radiation treatment for brain metastases affects thinking and memory over a year to help improve future care for patients.
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Evaluating tumor types in pancreatic cancer patients receiving FOLFIRINOX treatment
This study is testing how different types of pancreatic cancer respond to the chemotherapy FOLFIRINOX before surgery to see if it helps make the tumors easier to remove.
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Using molecular subtype analysis to improve treatment for metastatic breast cancer
This study is testing if knowing the specific type of breast cancer at a molecular level can help doctors make better treatment choices for patients with metastatic breast cancer.
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CAR T-Cell Therapy for Neuroblastoma and Osteosarcoma
This study is testing a new CAR T-cell therapy for children with hard-to-treat neuroblastoma and osteosarcoma to see if it can better fight their cancer while keeping them safe from serious side effects.
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Registry for adults with plasma cell disorders
This study is creating a registry for adults with plasma cell disorders like multiple myeloma to track their health and care experiences over time while also collecting blood samples for future research.
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Combining ulixertinib and palbociclib for advanced pancreatic and solid tumors
This study is testing a new combination of two drugs, ulixertinib and palbociclib, to see if they can safely help adults with advanced solid tumors, including pancreatic cancer and melanoma, who haven't responded to other treatments.
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Registry of older patients with cancer
This study collects health information from older cancer patients to create a registry that helps improve care and research for seniors with cancer.
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Collection of tissue, blood, and body fluid samples from patients with hematologic cancer
This study is collecting tissue, blood, and body fluid samples from patients with blood cancers to help improve cancer research and patient care.
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Examining how molecular markers relate to breast cancer treatment responses
This study is trying to find out if certain markers in tumor and blood samples can help predict how well women with advanced breast cancer will respond to treatment.
Quick answers
How many clinical trials run by UNC Lineberger Comprehensive Cancer Center are recruiting right now?
73, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 4 countries. The most sites are in United States (71 trials), South Africa (1 trial), Malawi (1 trial), Uganda (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 15, Phase 1: 11, Phase 1/2: 3, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.