Using brain tumor tissue to predict drug response

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the feasibility of using patient-derived explants (PDE) from resected central nervous system (CNS) tumors to predict drug response in both pediatric and adult patients. By testing tumor tissue ex vivo, the study seeks to generate drug sensitivity scores that could help identify the most effective therapies for individuals with CNS tumors. The research addresses the challenge of tumor heterogeneity and aims to establish a functional precision oncology platform for better treatment outcomes.

Why it matters

Who can join: the full rules

In order to participate in this study a subject must meet all of the eligibility criteria outlined below.

Inclusion Criteria:

1. Written informed consent obtained to participate in the study and HIPAA authorization for the release of personal health information or written assent and parental consent for pediatric subjects or surrogate consent provided by the subject's legally authorized guardians.
2. A diagnosis of a tumor residing in the central nervous system with surgery plan to have surgical resection.
3. The subject is willing and able to comply with study procedures based on the judgment of the investigator or protocol designer.

Exclusion Criteria:

1. All subjects must not meet any of the following exclusion criteria prior to enrollment to participate in this study:

   Any serious medical or psychiatric disorder that would interfere with the subject's ability to give informed consent.
2. Incarcerated individuals.

Where it's running

• UNC Lineberger Comprehensive Cancer Center
  Chapel Hill, North Carolina, United States Recruiting

Study contacts

• Principal investigator: Andrew B Satterlee, PhD — UNC Lineberger Comprehensive Cancer Center
• Study coordinator: Devin McCarthy
• Email: devin_mccarthy@med.unc.edu
• Phone: 919-966-7654

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.