Sponsor or institution
Clinical trials and research at Mayo Clinic Rochester
As of November 12, 2026, Find a Trial lists 941 NIH-funded research projects at this institution, with $655.1 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 941NIH research projects
NIH-funded research (newest 40 of 941)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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All of Us Biobank expansion and biospecimen program
A large Mayo Clinic–led project to collect and store biological samples from a diverse group of adults in the U.S. to advance precision medicine.
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How baclofen and spinal cord stimulation interact in people with spinal cord injury
This study looks at how a common antispasmodic medicine (baclofen) works together with spinal cord stimulation in people who have spinal cord injuries and live with spasticity.
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Pragmatic midodrine trial to reduce ICU vasopressor use in septic shock
A practical, patient-focused trial tests whether taking oral midodrine can lessen the need for IV vasopressors and shorten ICU stays for people with sepsis-related low blood pressure.
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Estrogen’s role in eye pressure and glaucoma risk
A Mayo Clinic team is studying how estrogen and its receptors might control eye pressure in people with a common form of glaucoma.
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Gut-brain connections in Parkinson’s disease: how the gut and environment shape symptoms
A Mayo Clinic team is studying how gut problems, environmental factors, and genetics together influence Parkinson’s disease and its GI symptoms to find biomarkers and better understanding of the disease.
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ARTFL LEFFTDS Frontotemporal Dementia study cycle 2
This NIH grant supports a longitudinal study to understand and track frontotemporal lobar degeneration (FTLD) and related disorders in people, aiming to uncover biomarkers and disease progression information that could help patients and families.
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ARTFL-LEFFTDS: Following Frontotemporal Degeneration Over Time
A long-term study following people at risk or with frontotemporal lobar degeneration to understand how the disease progresses and identify markers that could guide future treatments.
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ARTFL-LEFFTDS: Longitudinal Frontotemporal Degeneration study cycle 2
A long-term Mayo Clinic study follows people with or at risk for frontotemporal dementia to better understand how the disease progresses and to identify potential biomarkers and paths for future treatments.
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ARTFL LEFFTDS Frontotemporal Degeneration study: ALLFTD2
A Mayo Clinic study follows people with or at risk for early-onset frontotemporal dementia to understand its causes and biomarkers and to explore future therapies.
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Liver Cirrhosis Network: Mayo Clinic's Clinical Research Center
A Mayo Clinic-led project will follow and help people with compensated cirrhosis, using data, imaging, and a big AI tool to predict when complications may happen and test whether a statin can improve outcomes.
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Cortical-noradrenaline signals in alcohol-driven actions
This grant explores how brain signals related to arousal and attention influence people’s (animal models) alcohol-seeking behavior after long-term drinking.
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Life-space and social connections in aging adults to detect early Alzheimer’s risk
A Mayo Clinic-led study will look at how everyday life patterns, like movement, isolation, and daily activities, relate to early signs of Alzheimer’s in adults aged 65 and older.
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AI-powered automatic echocardiography reporting for better heart care
A Mayo Clinic team is developing an AI-enabled system to automatically interpret echocardiograms and generate reports for patients with heart problems.
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Breathing and perception: how body rhythms shape brain signals and choices
A Mayo Clinic team will study how breathing and other body signals influence brain activity and how we see and respond to things in the world.
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Aging and Alzheimer’s risk in African Americans through social and environmental factors
This project explores how social and environmental factors affect Alzheimer’s risk in African American adults and aims to enroll and follow a diverse group to understand what drives memory decline.
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HeartShare Clinical Center: advancing understanding of HFpEF at Mayo Clinic
A Mayo Clinic team is joining the HeartShare Consortium to study heart failure with preserved ejection fraction (HFpEF) and explore new ways to diagnose and treat it.
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All of Us Biobank expansion and biospecimen program
A large-scale project to keep expanding and improving the All of Us Biobank so researchers can use biospecimens and data to advance personalized medicine.
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Personalized genomic risk data to help prevent heart disease
A Mayo Clinic-led project is using electronic health records and genetic information to identify the risk of heart disease for tens of thousands of people and to see how this information affects their care.
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Tourette disorder: how non-coding changes and somatic CNVs may influence risk
A Mayo Clinic team is examining whether non-coding genetic changes and somatic copy number variations contribute to Tourette disorder in children.
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Novel combination therapy for non-Hodgkin lymphoma in people and dogs
A new treatment combo using an oncolytic virus and other therapies is being tested to help people with hard-to-treat non-Hodgkin lymphoma, with studies also involving dogs to better understand responses.
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A tissue slice model to test treatments for Pneumocystis pneumonia in people with HIV/AIDS
Researchers are creating a lung-slice model to study Pneumocystis jirovecii pneumonia and test potential treatments using tissue from infected, immunosuppressed mice to better predict what might help people with HIV/AIDS.
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Understanding why some adult brains have lots of genetic changes
Researchers are studying why some people’s brain cells accumulate mosaic genetic changes as they age, which might influence brain diseases or cancer risk.
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Falls and brain changes in older adults who don’t yet show dementia
Researchers at Mayo Clinic will study why people over 65 fall, by looking at how brain and body systems work together during walking and thinking tasks.
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CD40's role in shaping natural antibody production and atherosclerosis
This grant tests how immune signals involving CD40 and CD40L influence natural antibody production and plaque development in atherosclerosis.
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Blocking bacterial pumps that drive antibiotic resistance
This work aims to find ways to block bacterial pumps so existing antibiotics can work better for people with drug-resistant infections.
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Liquid biopsy for monitoring high-grade glioma using patient-specific DNA junctions
A Mayo Clinic team tests a blood test that looks for unique tumor DNA pieces in glioblastoma patients to monitor disease without frequent scans.
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Blocking bacterial drug pumps to fight antibiotic resistance
This project develops protein-based blockers (like antibody fragments) that plug bacterial pumps so antibiotics work better for people with drug-resistant infections.
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Detecting cancer risk and treatment response in NF1 nerve tumors using cfDNA markers
A doctor-led study will test blood-based DNA markers to detect when NF1-related nerve tumors become malignant and to monitor how well treatment is working.
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Cyclin D1 and DNA Repair in Mantle Cell Lymphoma: A Path to New Therapies
A clinician-researcher at Mayo Clinic is pursuing advanced training and research to understand how Cyclin D1 drives replication stress and to explore new targeted treatments for high-risk mantle cell lymphoma.
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Azithromycin vs doxycycline with beta-lactam in hospitalized adults with pneumonia
In hospitalized adults with community-acquired pneumonia, this study will compare two antibiotic combinations to see which works better and is safer.
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Personalized medicine approach to urinary stone disease
A research project using genetic information and AI tools to improve how doctors predict risk and tailor treatment for people with urinary stone disease.
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Overcoming Immunotherapy Resistance in Metastatic Gastric/Esophageal Cancer
A Mayo Clinic-led study aims to find better combos of immune therapy and standard treatment to help people with metastatic gastric and esophageal cancer who don’t respond well to current options.
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Improving outcomes for sarcoma patients through subtype-specific NCI trials
A Mayo Clinic-led effort to run and complete targeted sarcoma clinical trials that focus on specific histologic subtypes to better tailor treatment for patients.
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Pathobiology of a liver disease linked to inflammation and scarring
A Mayo Clinic team is studying why certain liver disease (MASH) becomes inflamed and scarred, with the goal of finding new ways to stop progression.
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Cholestatic Liver Disease: How Cholangiocytes Trigger Inflammation and Neutrophil Attack
Researchers are exploring how bile duct cells in PSC trigger inflammation and recruit immune cells, with the goal of identifying new treatment strategies.
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Discovering ADPKD Modifier Genes with Zebrafish Genetics
Aims to find genetic factors that influence how adult ADPKD shows up in patients using zebrafish as a model.
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Propofol-triggered high triglycerides: understanding causes and guiding care
This project looks at why propofol can raise triglycerides and how we can predict, monitor, and manage it to keep patients safer.
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Understanding iPSC reprogramming with a one-cycle measles vector
A Mayo Clinic team is testing a new one-cycle measles-virus–based system to efficiently turn adult cells into stem cells that could one day help treat degenerative diseases.
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Ultrasound markers to measure Crohn’s disease activity
A Mayo Clinic team is testing new 3D ultrasound methods to reliably track inflammation and scarring in Crohn’s disease using safe, affordable imaging that could replace more costly scans.
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Digital marker to measure delirium severity in ICU patients
A Mayo Clinic-led study will test a passive digital tool to measure how severe delirium is in adults in the ICU, with the goal of helping clinicians intervene earlier.
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