ARTFL-LEFFTDS: Following Frontotemporal Degeneration Over Time
Official title: ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration, Cycle 2 (ALLFTD2)
Funded at Mayo Clinic Rochester · NIH-11595431 · Data updated 2026-11-12
A long-term study following people at risk or with frontotemporal lobar degeneration to understand how the disease progresses and identify markers that could guide future treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 15, 2019 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $123,012 |
| NIH project number | 3U19AG063911-07S3 |
| Project ID | NIH-11595431 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals diagnosed with frontotemporal lobar degeneration or with familial risk factors (MAPT, GRN, C9orf72 mutations) who are willing to participate in long-term follow-up.
✕Less likely to help
Patients not interested in long-term follow-up or not meeting the genetic/familial criteria may not benefit from this study.
What this research studies
This study tracks participants over many years to observe the natural history of frontotemporal lobar degeneration, including genetic forms. Researchers collect clinical data, imaging, and biomarkers to identify patterns associated with different disease subtypes. The goal is to build a resource that helps scientists develop targeted therapies and improve patient care in the future. Participants may undergo regular assessments and biospecimen collection as part of an ongoing observational framework.
Why it matters
Potential benefit: Could advance understanding of FTLD and pave the way for personalized therapies and better diagnostic tools.
How similar studies have gone: Previous ARTFL and LEFFTDS studies have built valuable longitudinal data that have informed understanding of FTLD progression.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Boeve, Bradley F — Mayo Clinic Rochester
- Study coordinator: Boeve, Bradley F
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.