Pathobiology of a liver disease linked to inflammation and scarring
Official title: Pathobiology of Nonalcoholic Steatohepatitis
Funded at Mayo Clinic Rochester · NIH-11447375 · Data updated 2026-11-12
A Mayo Clinic team is studying why certain liver disease (MASH) becomes inflamed and scarred, with the goal of finding new ways to stop progression.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 30, 2021 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $787,421 |
| NIH project number | 2R01DK130884-06 |
| Project ID | NIH-11447375 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults with metabolic liver disease suspected or diagnosed as MASH who may provide liver tissue samples or participate in related studies.
✕Less likely to help
People without MASH or those unwilling to participate in tissue-based research may not benefit.
What this research studies
This project looks at how immune cells, especially CD4 T cells, contribute to liver inflammation and fibrosis in MASH. Using human liver samples and mouse models, researchers plan to map cellular and molecular changes and test how specific signals drive fibrotic pathways. The work aims to identify potential therapies that could reduce scarring and prevent liver failure in patients with this disease.
Why it matters
Potential benefit: If successful, the research could lead to new treatments that slow or halt liver fibrosis in people with MASH, potentially preventing liver failure and cancer.
How similar studies have gone: Previous studies have linked cytotoxic CD4 T cells to liver fibrosis, supporting this approach, though translating findings to therapies remains challenging.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Hirsova, Petra — Mayo Clinic Rochester
- Study coordinator: Hirsova, Petra
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.