Propofol-triggered high triglycerides: understanding causes and guiding care
Official title: Propofol-associated Hypertriglyceridemia: a mechanistic and causal inference analysis
Funded at Mayo Clinic Rochester · NIH-11447119 · Data updated 2026-11-12
This project looks at why propofol can raise triglycerides and how we can predict, monitor, and manage it to keep patients safer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 1, 2026 |
| Project end | April 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $781,013 |
| NIH project number | 1R01HL183399-01A1 |
| Project ID | NIH-11447119 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults in critical care who receive propofol for sedation and may develop hypertriglyceridemia.
✕Less likely to help
Patients not exposed to propofol or without lipid abnormalities may not benefit directly.
What this research studies
Propofol is a common sedative for patients on breathing machines, but it can raise triglyceride levels to dangerous levels in some patients. The study will follow a group of critically ill adults, measure triglycerides and lipoprotein profiles, and analyze data to identify patterns and possible causal factors. Researchers aim to translate these findings into practical guidance for when and how to monitor triglycerides and adjust sedation in the ICU. The goal is to turn a variable lab value into a well-understood syndrome with clear management steps.
Why it matters
Potential benefit: If successful, clinicians will have evidence-based strategies to monitor and manage P-HTG, potentially reducing mortality and complications for ICU patients.
How similar studies have gone: Previous work suggests P-HTG is linked to worse outcomes, but comprehensive management guidance is lacking, making this study largely exploratory yet with actionable potential.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Yadav, Hemang — Mayo Clinic Rochester
- Study coordinator: Yadav, Hemang
Related research
Other NIH-funded projects on the same topics.
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-
Ion775 for high triglyceride levels: safety, tolerability, and how well it works
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-
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This registry collects health and genetic information from people in Russia who have very high triglycerides (≥10 mmol/L) to see what their causes, care, and outcomes look like.
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MAR001 for adults with high triglycerides and remnant cholesterol
This trial will try the drug MAR001 to lower post-meal triglycerides and remnant cholesterol in adults with elevated triglyceride levels.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.