HeartShare Clinical Center: advancing understanding of HFpEF at Mayo Clinic
Official title: Mayo Clinic HeartShare Clinical Center
Funded at Mayo Clinic Rochester · NIH-11528998 · Data updated 2026-11-12
A Mayo Clinic team is joining the HeartShare Consortium to study heart failure with preserved ejection fraction (HFpEF) and explore new ways to diagnose and treat it.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 10, 2021 |
| Project end | January 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $424,166 |
| NIH project number | 3U01HL160226-05S1 |
| Project ID | NIH-11528998 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with heart failure symptoms suspected or diagnosed as HFpEF who are treated at Mayo Clinic and enrolled in HeartShare-related studies.
✕Less likely to help
Patients not involved in HFpEF research or outside Mayo Clinic HeartShare-related cohorts may not directly benefit.
What this research studies
At Mayo Clinic, researchers will partner with HeartShare investigators to uncover why HFpEF happens and how to tailor therapies. They will collect and analyze clinical information and use machine learning to identify distinct HFpEF subtypes based on multiple organ and aging-related factors. The goal is to create a mechanistic phenotyping approach that can guide future clinical trials and, ultimately, personalized care for people with HFpEF.
Why it matters
Potential benefit: If successful, patients with HFpEF could receive more targeted diagnoses and therapies tailored to their specific disease mechanism.
How similar studies have gone: Prior work shows promise in using phenotyping and ML to identify HFpEF subgroups, but this approach remains exploratory and requires further validation.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Borlaug, Barry a. — Mayo Clinic Rochester
- Study coordinator: Borlaug, Barry a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.