ARTFL LEFFTDS Frontotemporal Dementia study cycle 2
Official title: ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration, Cycle 2 (ALLFTD2)
Funded at Mayo Clinic Rochester · NIH-11595432 · Data updated 2026-11-12
This NIH grant supports a longitudinal study to understand and track frontotemporal lobar degeneration (FTLD) and related disorders in people, aiming to uncover biomarkers and disease progression information that could help patients and families.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 15, 2019 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $540 |
| NIH project number | 3U19AG063911-07S4 |
| Project ID | NIH-11595432 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with or at risk for frontotemporal lobar degeneration, including familial forms, who are willing to participate in long-term follow-up.
✕Less likely to help
Some participants may not experience direct personal benefit, as research aims to improve knowledge and future treatments rather than immediate care for each person.
What this research studies
This project follows people with FTLD, including inherited forms, over time to map how the disease starts and progresses. It looks at proteins linked to FTLD and how they relate to symptoms and brain changes, with the goal of identifying markers that predict outcomes. Researchers also build on prior ARTFL/LEFFTDS work to refine approaches for diagnosis and monitoring and to explore how new therapies might work. Participation would involve regular assessments, imaging, and biomarker studies over multiple years so patients and their families could contribute to advances in care.
Why it matters
Potential benefit: If successful, findings could lead to earlier diagnosis, better monitoring, and new targets for therapies to slow or treat FTLD in patients.
How similar studies have gone: Previous ARTFL/LEFFTDS work has established a strong framework and meaningful insights, guiding ongoing progress in FTLD research.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Boeve, Bradley F — Mayo Clinic Rochester
- Study coordinator: Boeve, Bradley F
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A long-term study following people at risk or with frontotemporal lobar degeneration to understand how the disease progresses and identify markers that could guide future treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.