Discovering ADPKD Modifier Genes with Zebrafish Genetics
Official title: Discovering ADPKD Modifier Genes and Mechanisms via Zebrafish Genetics
Funded at Mayo Clinic Rochester · NIH-11447128 · Data updated 2026-11-12
Aims to find genetic factors that influence how adult ADPKD shows up in patients using zebrafish as a model.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | August 1, 2026 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $748,694 |
| NIH project number | 1R01DK144208-01A1 |
| Project ID | NIH-11447128 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to patients directly; the study uses zebrafish models to understand human disease modifiers.
✕Less likely to help
This research does not recruit patients and may not benefit individuals directly.
What this research studies
This project uses adult zebrafish to quickly discover genetic modifiers of autosomal dominant polycystic kidney disease. Researchers will study genes linked to ADPKD, create zebrafish models, and test how these genes affect kidney development and disease features. The work includes advanced gene-editing methods and leveraging existing ADPKD gene data to identify modifiers that could become targets for therapy.
Why it matters
Potential benefit: If successful, findings could reveal new targets for therapies that modify disease severity in ADPKD patients.
How similar studies have gone: Preliminary data show the zebrafish model can reflect key ADPKD pathways and modifier screening is feasible.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Xu, Xiaolei — Mayo Clinic Rochester
- Study coordinator: Xu, Xiaolei
Related research
Other NIH-funded projects on the same topics.
-
All of Us Biobank expansion and biospecimen program
A large Mayo Clinic–led project to collect and store biological samples from a diverse group of adults in the U.S. to advance precision medicine.
-
How baclofen and spinal cord stimulation interact in people with spinal cord injury
This study looks at how a common antispasmodic medicine (baclofen) works together with spinal cord stimulation in people who have spinal cord injuries and live with spasticity.
-
Pragmatic midodrine trial to reduce ICU vasopressor use in septic shock
A practical, patient-focused trial tests whether taking oral midodrine can lessen the need for IV vasopressors and shorten ICU stays for people with sepsis-related low blood pressure.
-
Estrogen’s role in eye pressure and glaucoma risk
A Mayo Clinic team is studying how estrogen and its receptors might control eye pressure in people with a common form of glaucoma.
-
Gut-brain connections in Parkinson’s disease: how the gut and environment shape symptoms
A Mayo Clinic team is studying how gut problems, environmental factors, and genetics together influence Parkinson’s disease and its GI symptoms to find biomarkers and better understanding of the disease.
-
ARTFL LEFFTDS Frontotemporal Dementia study cycle 2
This NIH grant supports a longitudinal study to understand and track frontotemporal lobar degeneration (FTLD) and related disorders in people, aiming to uncover biomarkers and disease progression information that could help patients and families.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.