ARTFL-LEFFTDS: Longitudinal Frontotemporal Degeneration study cycle 2
Official title: ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration, Cycle 2 (ALLFTD2)
Funded at Mayo Clinic Rochester · NIH-11595430 · Data updated 2026-11-12
A long-term Mayo Clinic study follows people with or at risk for frontotemporal dementia to better understand how the disease progresses and to identify potential biomarkers and paths for future treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 15, 2019 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $451,127 |
| NIH project number | 3U19AG063911-07S2 |
| Project ID | NIH-11595430 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include individuals with FTLD symptoms or a family history suggestive of dominantly inherited FTLD (MAPT, GRN, or C9orf72 mutations) who are willing to undergo periodic evaluations.
✕Less likely to help
People without FTLD symptoms or a family history of FTLD may not directly benefit from the findings.
What this research studies
This program tracks individuals over time to map how frontotemporal lobar degeneration progresses, with a focus on the two main protein types involved and how inherited genetic factors influence disease. Researchers collect clinical information, imaging data, and biomarkers to build a comprehensive picture of FTLD in younger patients. The study aims to identify markers that could guide future therapies and improve diagnosis. Participants may have a familial risk or established FTLD-related symptoms and will receive regular assessments and coordinated care through the Mayo Clinic team.
Why it matters
Potential benefit: If successful, the study could lead to earlier diagnosis and new targets for treatments that slow or halt disease progression.
How similar studies have gone: Prior ARTFL/LEFFTDS efforts have shown value in linking biomarkers and clinical trajectories to disease progression; this cycle builds on those foundations with expanded data.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Boeve, Bradley F — Mayo Clinic Rochester
- Study coordinator: Boeve, Bradley F
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ARTFL LEFFTDS Frontotemporal Dementia study cycle 2
This NIH grant supports a longitudinal study to understand and track frontotemporal lobar degeneration (FTLD) and related disorders in people, aiming to uncover biomarkers and disease progression information that could help patients and families.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.