Personalized medicine approach to urinary stone disease
Official title: An individualized medicine approach to urinary stone disease
Funded at Mayo Clinic Rochester · NIH-11448990 · Data updated 2026-11-12
A research project using genetic information and AI tools to improve how doctors predict risk and tailor treatment for people with urinary stone disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | August 5, 2022 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $818,020 |
| NIH project number | 2R01DK133171-05 |
| Project ID | NIH-11448990 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with urinary stone disease, especially those with a family history or recurrent stones, who consent to genetic and clinical data analysis.
✕Less likely to help
Individuals without urinary stone disease or those unwilling to share genetic/clinical data may not benefit directly.
What this research studies
This project focuses on understanding the genetic factors behind urinary stone disease and how they interact with lifestyle and other data. It uses AI methods to analyze large genetic and clinical datasets, with a goal of identifying high-risk individuals and informing personalized treatment decisions. The work leverages a large patient registry from the Rare Kidney Stone Consortium and collaborates with genetics, bioinformatics, and cell biology experts to connect genetic risk with potential therapies and lifestyle changes.
Why it matters
Potential benefit: If successful, the project could lead to more accurate risk prediction and personalized prevention strategies for urinary stone disease.
How similar studies have gone: Previous genetic studies have linked multiple risk genes to USD, and integrating AI with genetics is an emerging but promising approach.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Harris, Peter C. — Mayo Clinic Rochester
- Study coordinator: Harris, Peter C.
Related research
Other NIH-funded projects on the same topics.
-
All of Us Biobank expansion and biospecimen program
A large Mayo Clinic–led project to collect and store biological samples from a diverse group of adults in the U.S. to advance precision medicine.
-
How baclofen and spinal cord stimulation interact in people with spinal cord injury
This study looks at how a common antispasmodic medicine (baclofen) works together with spinal cord stimulation in people who have spinal cord injuries and live with spasticity.
-
Pragmatic midodrine trial to reduce ICU vasopressor use in septic shock
A practical, patient-focused trial tests whether taking oral midodrine can lessen the need for IV vasopressors and shorten ICU stays for people with sepsis-related low blood pressure.
-
Estrogen’s role in eye pressure and glaucoma risk
A Mayo Clinic team is studying how estrogen and its receptors might control eye pressure in people with a common form of glaucoma.
-
Gut-brain connections in Parkinson’s disease: how the gut and environment shape symptoms
A Mayo Clinic team is studying how gut problems, environmental factors, and genetics together influence Parkinson’s disease and its GI symptoms to find biomarkers and better understanding of the disease.
-
ARTFL LEFFTDS Frontotemporal Dementia study cycle 2
This NIH grant supports a longitudinal study to understand and track frontotemporal lobar degeneration (FTLD) and related disorders in people, aiming to uncover biomarkers and disease progression information that could help patients and families.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.