ARTFL LEFFTDS Frontotemporal Degeneration study: ALLFTD2
Official title: ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration, Cycle 2 (ALLFTD2)
Funded at Mayo Clinic Rochester · NIH-11595429 · Data updated 2026-11-12
A Mayo Clinic study follows people with or at risk for early-onset frontotemporal dementia to understand its causes and biomarkers and to explore future therapies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 15, 2019 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $284,525 |
| NIH project number | 3U19AG063911-07S1 |
| Project ID | NIH-11595429 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with familial or sporadic frontotemporal dementia or related FTLD conditions, including those at risk or in early stages, may be eligible.
✕Less likely to help
People without FTLD or a closely related condition are unlikely to benefit from this specific study.
What this research studies
This project continues a long-term study of people with FTLD and related conditions, tracking symptoms, biology, and imaging over time. Researchers work to identify biomarkers and genetic factors linked to disease progression, aiming to inform better diagnosis and future treatments. Participants may undergo interviews, cognitive tests, imaging, and collection of samples to build a richer picture of how FTLD evolves. The effort emphasizes collaboration across families and clinicians to translate findings into care options.
Why it matters
Potential benefit: Better understanding of FTLD could lead to earlier diagnosis and new targets for therapy that slow or modify disease progression.
How similar studies have gone: Previous ARTFL/LEFFTDS studies have generated valuable biomarkers and natural history data that inform ongoing research.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Boeve, Bradley F — Mayo Clinic Rochester
- Study coordinator: Boeve, Bradley F
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.