Understanding iPSC reprogramming with a one-cycle measles vector
Official title: Understanding iPSC reprogramming using single cycle Measles vector
Funded at Mayo Clinic Rochester · NIH-11445999 · Data updated 2026-11-12
A Mayo Clinic team is testing a new one-cycle measles-virus–based system to efficiently turn adult cells into stem cells that could one day help treat degenerative diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | July 14, 2026 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $795,316 |
| NIH project number | 1R01AI195557-01A1 |
| Project ID | NIH-11445999 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates would be adults whose cells are used to generate patient-specific iPSCs for future disease modeling or therapy development.
✕Less likely to help
Direct patient benefit would depend on future translation; this grant primarily advances basic methods.
What this research studies
This project uses a novel one-cycle measles virus vector to deliver the four reprogramming factors in a single genome, aiming to make higher-quality human iPSCs from adult cells. Researchers will compare the new vector to existing methods and analyze how reprogramming proceeds, including the role of the innate immune response. The work focuses on human fibroblasts and aims to produce iPSCs that meet clinical-grade standards for potential future therapies. If successful, this approach could clarify the steps needed to generate safe, effective iPSCs for patients with degenerative conditions.
Why it matters
Potential benefit: If successful, this method could yield more reliable, clinically suitable iPSCs for regenerative medicine.
How similar studies have gone: Previous work shows iPSCs can be generated with various vectors; this study tests a potentially more efficient vector system.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Devaux, Patricia — Mayo Clinic Rochester
- Study coordinator: Devaux, Patricia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.