Personalized genomic risk data to help prevent heart disease
Official title: EHR-based Genomic Discovery and Implementation
Funded at Mayo Clinic Rochester · NIH-11513521 · Data updated 2026-11-12
A Mayo Clinic-led project is using electronic health records and genetic information to identify the risk of heart disease for tens of thousands of people and to see how this information affects their care.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | August 15, 2011 |
| Project end | April 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $666,604 |
| NIH project number | 3U01HG006379-13S2 |
| Project ID | NIH-11513521 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults who were part of the eMERGE network with genomic risk assessments and active follow-up data, particularly those at risk for coronary disease and enrolled at partner sites including Mountain Park Health Center.
✕Less likely to help
Patients not recently receiving genomic risk information or not linked to the electronic health record–based data may not directly benefit.
What this research studies
This project builds on a network that shares genomic risk scores for common conditions with patients and uses family history data collected through a patient-friendly tool. It tracks how doctors and patients use genome-informed risk information over time, and analyzes healthcare utilization after returning genomic risk results. The effort includes analyzing 6-month and 12-month outcomes for patients and coordinating with multiple sites to prepare robust, analysis-ready datasets. If you have coronary disease or are at risk, this research could influence how genetic information informs your care in the future. The work is centered at Mayo Clinic in Rochester with collaboration from other eMERGE network sites.
Why it matters
Potential benefit: If successful, results could improve how genomic risk information guides prevention and management of coronary disease in clinical care.
How similar studies have gone: Previous phases of eMERGE demonstrated feasibility of returning polygenic risk scores and integrating genomic data into clinical care.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Sharp, Richard R. — Mayo Clinic Rochester
- Study coordinator: Sharp, Richard R.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.