Sponsor or institution
Clinical trials and research at Jackson Laboratory
As of November 12, 2026, Find a Trial lists 204 NIH-funded research projects at this institution, with $159.2 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 204NIH research projects
NIH-funded research (newest 40 of 204)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Mouse Phenome Project: a shared mouse data resource for understanding human disease
A large, centralized database of mouse phenotypes is created to help researchers study human diseases by comparing mouse and human biology.
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Pediatric Cancer Drug Testing Coordinating Center
A coordinating center is coordinating how young patients’ cancer models are tested with targeted drugs to help improve pediatric cancer outcomes.
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Increasing the usefulness of pediatric genomic medicine with Exomiser
A pediatric genetic diagnosis project is improving how we use sequencing data to find rare disease causes in children.
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Modeling Hearing and Balance Disorders in Mice: HEar@JAX Workshop
A five-day workshop at The Jackson Laboratory trains researchers in using mouse models to study hearing and balance, with hands-on labs for 20 participants.
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Age-stratified gut-on-a-chip model to study microbiome-driven aging of the lining of the intestine
A human gut-on-a-chip model will be created to study how aging-related changes in the gut lining interact with microbiome shifts, using patient-derived tissues and age-appropriate microbes.
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Single-cell long-read sequencing to map cancer RNA variants
A cancer research grant aims to make advanced single-cell RNA sequencing more accurate and widely usable to understand how different RNA isoforms affect brain and breast cancers.
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PDX Data Commons and Coordination Center for patient-derived cancer models
A national effort to share and analyze patient-derived cancer models to find effective drug combinations for specific cancer patients.
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Molecular mapping of human gene function through multi-omic profiling
A program is testing how turning off or reducing specific human genes changes cells over time using advanced sequencing and other lab methods.
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Disease models to study autoimmune diseases and test therapies
A program to create and test animal models of human autoimmune diseases so researchers can understand disease mechanisms and try new treatments.
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Resource and service hub for Aran-Duchenne disease mouse models
A program to publicize and distribute Aran-Duchenne mouse models and related services to researchers and clinicians.
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Bioinformatics Core at the Jackson Laboratory supports precision genetics data for preclinical models
A dedicated bioinformatics core helps scientists manage and share high-quality genetic and modeling data from preclinical studies to advance personalized approaches.
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Preclinical and Co-Clinical Core for Patient-Specific Therapeutics
A program that tests new treatments for human diseases using mouse models made from patient data, with a strong emphasis on translating findings toward future patient care.
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Coordination of a Center for Precision Genetics
A national center-led effort coordinates experts to advance precision genetics, support disease-focused projects, and manage resources to accelerate discoveries that could help patients with genetic disorders.
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Center for Precision Genetics facilitates smarter genetic research
A national genetics center at Jackson Laboratory coordinates experts and resources to accelerate precision genetics research and enable collaboration.
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Multi-Organ Multi-Omics Computational Framework to Understand Iron Disorders
A research project is turning big-picture data about iron levels in blood and tissues into insights that could help people with iron-related illnesses.
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Machine learning-based frailty index for diverse mice
A machine-learning powered frailty score using videos of diverse mice to better understand aging and its health impacts.
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Understanding KIF1A-related neurological disease
This project builds mouse models of KIF1A-related neurological disorder to help develop treatments for children and adults with KAND.
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Lung-supporting cells in the spread of breast cancer to the lungs as we age
This project looks at how aging changes the lung environment to help breast cancer spread there.
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Understanding why some people become more sensitive to cocaine and less likely to develop addiction
Researchers at Jackson Laboratory are studying why genetic differences make some individuals more likely to develop cocaine use disorder, by looking at how repeated cocaine exposure changes behavior and brain circuits in animal models.
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Impulsivity and Addiction Genetics in Animal Models
A study explores why some people and animal models act more impulsively with rewards, aiming to connect impulsive behavior to genetic and brain mechanisms linked to addiction.
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Mouse resources and validation core for addiction genetics models
A center at The Jackson Laboratory helps create and validate mouse models to study addiction, using special mouse populations and CRISPR to generate and share new disease-relevant strains.
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Behavioral Phenotyping Core supports addiction research in mice
A large NIH grant funds a core that helps researchers study how natural behavioral traits relate to drug self-administration in genetically diverse mice.
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Integrative Genetics and Genomics Core for Addiction Research
A core resource at a leading research center helps scientists study how genetics and biology influence psychostimulant addiction, using advanced data and molecular analyses.
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Administrative Core for the Center for Systems Neurogenetics of Addiction
A central core grants and coordinates resources for a multi-site research effort studying genetic and brain factors linked to psychostimulant addiction, using mouse models and computational tools.
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Center for Systems Neurogenetics of Addiction (CSNA)
A research center is studying how genetic and brain factors influence cocaine addiction, using mouse models and human genetics to understand why some people are more prone to drug seeking.
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Spatial patterns of RNA isoforms in aging breast cancer development
A new approach will map where different RNA isoforms appear in aging breast tissue to understand how cancer starts and evolves.
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Knockout Mouse Project to map human-relevant genes and disease links
A project at The Jackson Laboratory plans to create and thoroughly study 600 engineered mouse lines to help understand how human genes work and how they relate to disease.
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Role of ARMS2 mutations in age-related macular degeneration
This grant explores how ARMS2 genetic changes may drive age-related macular degeneration and how these changes cause AMD-related eye damage in mouse models.
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Mitochondrial DNA Instability and ZBP1 in chemotherapy-related heart damage
This grant tests how a heart-protective pathway involving ZBP1 might prevent heart damage caused by common cancer drugs like doxorubicin.
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AI to find biological markers linked to exceptional longevity
This project uses explainable artificial intelligence to combine many types of genetic and molecular data to find markers tied to living to very old ages, focusing on centenarians and related cohorts.
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Retinal Disease: Molecular Basis and Pathophysiology
A gene mutation linked to retinal disease is studied to understand how it changes cellular pathways and leads to vision problems.
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Site-specific insertion of large DNA into mouse and human stem cells using Cas9-Bxb1 tools
A research project aims to improve how we insert large DNA pieces into mice and human stem cells to better model breast cancer and other diseases.
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Helping the brain rewire to restore movement after stroke
Researchers are trying to reactivate learning-related brain cells to help adults regain movement after a stroke.
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Interventions to Slow Aging in Mammals
This NIH grant funds studies testing drugs to see if they can extend lifespan and delay age-related diseases in mice, with the goal of informing future human anti-aging therapies.
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Improved Reporter Mice to Advance Gene Editing
A small research project uses specially designed mice to help scientists test new gene editing tools and understand how they work inside living bodies.
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Molecular Gene Knockout Resource Center for Human iPSCs
A national center will systematically create and study human iPSCs with 250 gene knockouts to uncover how these genes affect early development and neurodevelopment.
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Human brain cell model to study myelination and axon-synapse problems in Alzheimer’s
A study will create a human cell model that mimics brain myelination and axon-synapse function to understand early changes in Alzheimer’s disease.
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Extending blood stem cell health in middle age
Researchers are working to keep blood-forming stem cells healthier in middle-aged adults to lower the later risk of blood cancers, heart disease, and diabetes.
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Understanding how autoimmune diabetes may trigger nerve damage
Researchers are studying how kinds of immune cells that attack the pancreas in type 1 diabetes might also start damaging nerves, with a special mouse model to help understand this connection.
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Genetics of the Neuromuscular Junction: Disease Mechanisms and Treatment Approaches
Researchers are studying how certain tRNA synthetase mutations cause inherited nerve disease and testing potential drug and gene therapies to help people with Charcot–Marie–Tooth disease.
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