PDX Data Commons and Coordination Center for patient-derived cancer models
Official title: PDXNet Data Commons and Coordinating Center
Funded at Jackson Laboratory · NIH-11404005 · Data updated 2026-11-12
A national effort to share and analyze patient-derived cancer models to find effective drug combinations for specific cancer patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jackson Laboratory NIH-funded |
| Lab location | 1 site (Bar Harbor, United States) |
| Project start | September 25, 2017 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $712,216 |
| NIH project number | 5U24CA224067-08 |
| Project ID | NIH-11404005 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients whose cancer models (PDXs or similar) are represented in the data resources or whose data contribute to shared analyses.
✕Less likely to help
Patients not represented in the PDX collections or whose cancer type is not captured in the shared datasets may not benefit directly.
What this research studies
This grant supports a centralized data hub and coordination center that gathers drug-response data from patient-derived xenografts (PDXs) and links it with detailed molecular profiles. It uses cloud computing and standardized datasets to enable large-scale analysis and sharing across researchers and repositories. The goal is to help identify promising anti-cancer drug combos that could move toward clinical testing in defined patient subgroups. By making resources and data widely accessible, researchers can accelerate translation from model systems to real patient care. The work empowers clinicians and patients by building a robust framework for evaluating treatments in personalized cancer contexts.
Why it matters
Potential benefit: If successful, it could speed up the identification of effective drug combinations for specific cancers, guiding personalized treatment decisions.
How similar studies have gone: Prior PDx data sharing efforts have enabled cross-institution analyses and improved understanding of drug responses.
Where this research is happening
-
Jackson Laboratory
Bar Harbor, United States Active
Researchers
- Principal investigator: Chuang, Jeffrey Hsu-Min — Jackson Laboratory
- Study coordinator: Chuang, Jeffrey Hsu-Min
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.