Bioinformatics Core at the Jackson Laboratory supports precision genetics data for preclinical models
Official title: Bioinformatics Section
Funded at Jackson Laboratory · NIH-11393945 · Data updated 2026-11-12
A dedicated bioinformatics core helps scientists manage and share high-quality genetic and modeling data from preclinical studies to advance personalized approaches.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jackson Laboratory NIH-funded |
| Lab location | 1 site (Bar Harbor, United States) |
| Project start | September 1, 2020 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $350,200 |
| NIH project number | 5U54OD030187-07 |
| Project ID | NIH-11393945 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to a specific patient group; this is a core infrastructure that supports translational research and future patient-focused studies.
✕Less likely to help
Direct patient benefit is not immediate; the core strengthens the data foundations for future research that could help patients.
What this research studies
The JAX Center for Precision Genetics Bioinformatics Core provides top-notch tools and workflows to design, manage, analyze, and share data from in vivo, cellular, and molecular projects. It focuses on data acquisition, curation, dissemination, and reuse to boost long-term data utility. The core has built an external portal for easy access to workflows, data, model organisms, and project tracking, and supports prioritizing mouse and cellular models for generation. In the next phase, it will ensure rigorous data processing and widely accepted practices to enable future reuse and traceability.
Why it matters
Potential benefit: If successful, researchers can more quickly translate preclinical findings into reliable models and potential therapies through better data reuse and collaboration.
How similar studies have gone: Similar bioinformatics cores have improved data sharing and reproducibility in large genetics projects and typically lead to faster discoveries.
Where this research is happening
-
Jackson Laboratory
Bar Harbor, United States Active
Researchers
- Principal investigator: Chesler, Elissa J — Jackson Laboratory
- Study coordinator: Chesler, Elissa J
Related research
Other NIH-funded projects on the same topics.
-
Mouse Phenome Project: a shared mouse data resource for understanding human disease
A large, centralized database of mouse phenotypes is created to help researchers study human diseases by comparing mouse and human biology.
-
Pediatric Cancer Drug Testing Coordinating Center
A coordinating center is coordinating how young patients’ cancer models are tested with targeted drugs to help improve pediatric cancer outcomes.
-
Increasing the usefulness of pediatric genomic medicine with Exomiser
A pediatric genetic diagnosis project is improving how we use sequencing data to find rare disease causes in children.
-
Modeling Hearing and Balance Disorders in Mice: HEar@JAX Workshop
A five-day workshop at The Jackson Laboratory trains researchers in using mouse models to study hearing and balance, with hands-on labs for 20 participants.
-
Age-stratified gut-on-a-chip model to study microbiome-driven aging of the lining of the intestine
A human gut-on-a-chip model will be created to study how aging-related changes in the gut lining interact with microbiome shifts, using patient-derived tissues and age-appropriate microbes.
-
Single-cell long-read sequencing to map cancer RNA variants
A cancer research grant aims to make advanced single-cell RNA sequencing more accurate and widely usable to understand how different RNA isoforms affect brain and breast cancers.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.